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MetabolomicsInfluenza A virus H1N1 infection alters sphingolipid metabolism in A549 cells
This study investigates metabolic alterations in A549 cells infected with influenza A virus H1N1 (WSN strain). Untargeted metabolomics analysis was performed using liquid chromatography coupled with mass spectrometry (LC-MS) in both positive and negative ionization modes. The study aims to character...
2026-07-29 | MTBLS15182 | MetaboLights
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
MetabolomicsA549 13C-labeled Cell Study
Not available
ORGANISM(S): Homo sapiens 
ST000148 | MetabolomicsWorkbench
MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV) infected A549 cells (24h post infection; four biological replicate sets). Data is related to the fractionation-free workflow described in Dave et al. (2014) (PMID: 25106423). Data is processed using MaxQuant (version 1.3.0.5)...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-08-08 | MSV000080032 | MassIVE
TranscriptomicsSMAD3 targets in A549 lung epithelial cells
TGF? activates a signal transduction cascade that results in the transcription of genes, primarily through the DNA-binding transcription factor SMAD3. The objective of this study is to identify SMAD3 binding targets and the molecular pathways affected by the TGF?1/SMAD3 signal transduction on a geno...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-26858 | biostudies-arrayexpress
MetabolomicsControl (DMSO 0.1%; v/v) and 10 µM DRB18 treated A549 lung cancer cells in vitro for 48 hours
Not available
ORGANISM(S): Homo sapiens 
ST001610 | MetabolomicsWorkbench
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using in-solution protein IEF followed by bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV)-infected A549 cells (24h post infection; five paired biological replicate sets). Data is related to the in-solution protein IEF workflow described in Dave et al. (2014) (PMID: 25106423). Data processed using MaxQuant (version...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-01-12 | MSV000079453 | MassIVE
MetabolomicsMetabolomics analysis of Vehicle (DMSO/PBS; (1:1) v/v) and DRB18 (10 mg/kg) treated A549 xenograft tumors
Not available
ORGANISM(S): Mus musculus 
ST001638 | MetabolomicsWorkbench
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