Sort   by:  
 Page size 
MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsIntermittent fasting promotes remodeling of neural and vascular networks in visceral white adipose tissue
Intermittent fasting (IF) improves metabolic health, in part by remodeling white adipose tissue (WAT), yet the underlying mechanisms remain elusive. Here, we show that IF induces coordinated neurovascular remodeling in visceral WAT, marked by increased angiogenesis and sympathetic innervation. Using...
ORGANISM(S): Mus musculus 
2026-07-13 | E-MTAB-16066 | biostudies-arrayexpress
ProteomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
ORGANISM(S): Homo sapiens (Human) 
2026-05-20 | PXD076314 | Pride
Nitrate  sialin2  er-mitochondria contacts  calcium signaling  lipid mobilization  adipose browning 
GenomicsATF4 mediates cold-induced adipose tissue browning by regulating MTHFD2 expression
ATF4 mediates cold-induced adipose tissue browning by regulating MTHFD2 expression
PRJNA1076873 | ENA
TranscriptomicsBrown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]
Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 2 weeks
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-68382 | biostudies-arrayexpress
ProteomicsThe Gut Microbiota Metabolite Succinate promotes Adipose Tissue Browning in Crohn’s Disease
In Crohn’s disease (CD), microbe-host interactions are altered, with changes in microbial’s communities and barrier defects leading to translocation of microbes to surrounding adipose tissue (AT). We evaluated the presence of beige AT depots in CD and questioned whether succinate and/or bacterial tr...
ORGANISM(S): Homo sapiens (Human) 
2022-09-14 | PXD030520 | Pride
Chron disease Microbiota Proteomics 
GenomicsSENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
PRJNA782557 | ENA
GenomicsSENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
PRJNA782879 | ENA
Sort   by:  
 Page size