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ProteomicsA small-molecule inhibitor targeting AKR1C1 suppresses cell proliferation and metastasis in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by highly invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis and has gained attention as an anticancer dru...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031082 | Pride
Alantolactone  akr1c1  anticancer  target identification  non-small cell lung cancer 
TranscriptomicsTranscription profiling of human HT29 cells sensitive and resistant to 10e-5M methotrexate
The abstract of the associated publication (Selga E, Noé V, Ciudad CJ. Biochemical Pharmacology 2007 Sep 8; Article in press) is the following:; While studying differentially expressed genes between sensitive and 10-5 M Methotrexate (MTX) resistant HT29 human colon cancer cells, we identified some ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9412 | biostudies-arrayexpress
GenomicsAKR1C1 Drives Oxaliplatin Chemoresistance by Activation of STAT3 in Colorectal Cancer
AKR1C1 Drives Oxaliplatin Chemoresistance by Activation of STAT3 in Colorectal Cancer
PRJNA984208 | ENA
TranscriptomicsAKR1C1 Drives Oxaliplatin Chemoresistance by Activation of STAT3 in Colorectal Cancer
AKR1C1, a member of the AKR1C family, has been identified as a key player in cancer progression, promoting cancer cell proliferation and inhibiting apoptosis. Here, we identified AKR1C1 as a potential crucial gene significantly associated with oxaliplatin (OXA) sensitivity and unfavorable clinical o...
ORGANISM(S): Mus musculus 
2024-12-11 | GSE235026 | GEO
GenomicsExpression data from AKR1C1 over-expression in Cal-27 cells or knockdown in HSC-2 cells, respectively
Expression data from AKR1C1 over-expression in Cal-27 cells or knockdown in HSC-2 cells, respectively
PRJNA489264 | ENA
UnknownAvasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling.
Not available
S-EPMC8195695 | biostudies-literature
TranscriptomicsExpression data from AKR1C1 over-expression in Cal-27 cells or knockdown in HSC-2 cells, respectively
To exmaine the AKR1C1 controls transcriptome in HNSCC cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with empty vector or AKR1C1 expression vector in Cal-27 cells and shLuc control or shAKR1C1 in HSC-2 cells
ORGANISM(S): Homo sapiens 
2019-12-18 | GSE119444 | GEO
UnknownMechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.
Not available
S-EPMC4891125 | biostudies-literature
UnknownAKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.
Not available
S-EPMC5771085 | biostudies-literature
UnknownLiquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism.
Not available
S-EPMC6616128 | biostudies-literature
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