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ProteomicsCharacterization of N-terminal acetylation of α-hemoglobin stabilizing protein (AHSP) by top-down high resolution mass spectrometry of oral fluids from human preterm newborns.
The project reports the identification in oral fluid samples of preterm newborns of AHSP (Alpha-hemoglobin Stabilizing Protein), an erythroid-specific protein forming stable complexes with free α-hemoglobin preventing its harmful aggregation and pro-oxidant activity during red blood cell development...
ORGANISM(S): Homo sapiens (Human) 
2025-07-18 | PXD061305 | Pride
Oral fluid top-down proteomics  preterm newborn biomarkers  alpha-hemoglobin stabilizing protein (ahsp)  lc-ms  neonatal hematological disorders 
Unknownα-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.
Not available
S-EPMC3707698 | biostudies-literature
UnknownRole of α-globin H helix in the building of tetrameric human hemoglobin: interaction with α-hemoglobin stabilizing protein (AHSP) and heme molecule.
Not available
S-EPMC4219717 | biostudies-literature
UnknownIncreased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).
Not available
S-EPMC11084795 | biostudies-literature
Unknownα-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.
Not available
S-EPMC3567680 | biostudies-literature
UnknownInsights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Not available
S-EPMC3322894 | biostudies-literature
UnknownCharacterization of N-Terminal Acetylated α-Hemoglobin Stabilizing Protein (AHSP) by Top-Down High-Resolution Mass Spectrometry From Human Preterm Newborns Oral Fluid.
Not available
S-EPMC12272030 | biostudies-literature
UnknownThe role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly.
Not available
S-EPMC2821148 | biostudies-literature
UnknownA cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.
Not available
S-EPMC2785579 | biostudies-literature
UnknownAnalysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein.
Not available
S-EPMC2700329 | biostudies-literature
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