alphaviruses - OmicsDI

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Expression profile of adult Drosophila melanogaster expressing a self-replicating RNA of Sindbis virus

Alphaviruses establish a persistent infection in arthropod vectors, which is essential for effective transmission of the virus to vertebrate hosts. The development of persistence in insects is not well understood, although it is thought to involve the innate immune response. Using a transgenic fly s...

ORGANISM(S): Drosophila melanogaster

2013-01-31 | E-GEOD-42726 | biostudies-arrayexpress

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion

PRJNA1214211 | ENA

Broad spectrum efficacy of BDGR-164 against neurotropic alphaviruses and correlates of protection

PRJNA1076535 | ENA

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion

Several alphaviruses bypass the blood-brain barrier (BBB), causing debilitating or fatal encephalitis. Sindbis virus (SINV) has been extensively studied in vivo to understand alphavirus neuropathogenesis; yet the molecular details of neuroinvasion at the BBB remain poorly understood. We investigated...

ORGANISM(S): Homo sapiens

2025-01-30 | GSE287658 | GEO

Venezuelan equine encephalomyelitis virus structure and its divergence from old world alphaviruses.

Not available

S-EPMC114521 | biostudies-literature

Mxra8 is a receptor for multiple arthritogenic alphaviruses.

Not available

S-EPMC5970976 | biostudies-literature

Vaccine elicitation and structural basis for antibody protection against alphaviruses.

Not available

S-EPMC10411218 | biostudies-literature

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells.