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TranscriptomicsTranscription profiling of human post mortem spinal cord grey matter from sporadic and familial ALS patients vs controls to identify amyotrophic lateral sclerosis (ALS) associated genes
Identification of amyotrophic lateral sclerosis (ALS) associated genes. Post mortem spinal cord grey matter from sporadic and familial ALS patients compared with controls.
ORGANISM(S): Homo sapiens 
2007-09-26 | E-GEOD-833 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of C9ORF72 ALS fibroblast
The purpose of this experiment was to compare the differences in transcript levels between RNA samples collected from fibroblasts from healthy control patients, amyotrophic lateral sclerosis (ALS) patients carrying an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene and...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1926 | biostudies-arrayexpress
MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
ProteomicsAnalyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets
Supporting MS data files for paper (doi:10.3389/fncel.2023.1327361) by Watts M.E. et al., titled "Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets". See attached pdf for index of MS files uploaded.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-25 | MSV000093190 | MassIVE
TranscriptomicsDistinct brain transcriptome profiles in c9orf72-associated and sporadic ALS
Increasing evidence suggests that defective RNA processing contributes to the development of amyotrophic lateral sclerosis (ALS). This may be especially true for ALS caused by a repeat expansion in C9orf72 (c9ALS), in which the accumulation of RNA foci and dipeptide-repeat proteins are expected to m...
ORGANISM(S): Homo sapiens 
2015-07-19 | E-GEOD-67196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of post-mortem brain cortex from healthy control patients and amyotrophic lateral sclerosis patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 (C9ORF72) gene
The purpose of this experiment was to compare differences in the transcript level between RNA samples collected from post-mortem motor cortex from healthy control patients and amyotrophic lateral sclerosis (ALS) patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading ...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1925 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.
Amyotrophic lateral sclerosis (ALS) is caused by the progressive degeneration of motor neurons. Mutations in the Cu/Zn superoxide dismutase (SOD1) are found in about 20% of patients with familial ALS. Mutant SOD1 causes motor neuron death through an acquired toxic property. Although, molecular mecha...
ORGANISM(S): Rattus norvegicus 
2008-12-18 | E-GEOD-7441 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsAn intricate interplay between astrocytes and motor neurons in ALS
Amyotrophic Lateral Sclerosis (ALS) results from the selective and progressive degeneration of motor neurons. Although the underlying disease mechanisms remain unknown, glial cells have been implicated in ALS disease progression. Here we examine the effects of glial cell/motor neuron interactions on...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-43879 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ALS skeletal muscle
Objective: to focus on the molecular mechanisms involved in the ALS related atrophy process that leads to selective wasting muscles . Design: gene expression profiling and real time PCR were performed on muscle biopsies
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-41414 | biostudies-arrayexpress
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