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ProteomicsConformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis
Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of monoclonal light chain (LC) and its fragments containing variable (VL) and portions of constant (CL) domains. AL patients feature either monoclonal free LCs circulating as covalent and noncovalent h...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD055570 | Pride
Igg  amyloid light chain hdx-ms  al amyloidosis  hydrogen/deuterium exchange mass spectrometry 
ProteomicsRole of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains
Immunoglobulin light chain (LC) amyloidosis is a life-threatening disease whose understanding and treatment is complicated by vast numbers of patient-specific mutations. To address molecular origins of the disease, we explored 14 patient-derived and engineered proteins related to κ1-family germline ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD039682 | Pride
Light chain amyloidosis  misfolded states  protein stability  protein dynamics  hdx ms  hydrogen deuterium exchange mass spectrometry 
ProteomicsStabilization of diverse amyloidogenic antibody light chains by small molecules revealed by hydrogen-deuterium exchange mass spectrometry
Antibody light chains can aggregate as amyloid fibrils to cause systemic AL amyloidosis. Amyloid deposition requires unfolding of the light chain from its native state, but the mechanistic details of how this occurs are not fully understood. Inhibiting amyloid formation by stabilizing the precursor ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-27 | PXD068745 | Pride
ProteomicsA conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation
Immunoglobulin light chain (LC) amyloidosis (AL) is a life-threatening human disease wherein free monoclonal LCs deposit in vital organs. To determine what makes some LCs amyloidogenic, we explored patient-based amyloidogenic and non-amyloidogenic recombinant LCs from the λ6 subtype prevalent in AL....
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD026528 | Pride
Light chain amyloidosis  protein conformation  hydrogen-deuterium exchange mass spectrometry  propagation of mutational effects  cdr loops 
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