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ProteomicsANGPTL4 binds to leptin receptor to regulate ectopic bone formation and fat metabolism
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR (db/db) and leptin (ob/ob) are not identical, and the cause remains unclear. Here, we show that db/db, but not ob/ob mice had defect in tenotomy-induced heterotopic ossification (HO), ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD043087 | Pride
Leptin receptor  angptl4  heterotopic ossification  fat metabolism 
GenomicsCharacterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice
PRJNA561718 | ENA
TranscriptomicsCharacterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice
ANGPTL4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric lymphadenopathy. Here, we studied the role of ANGPTL4 in lipid uptake in macrophages ...
ORGANISM(S): Mus musculus 
2019-08-24 | GSE136240 | GEO
GenomicsSuppression of ANGPTL4 Reprograms Endothelial Cell Metabolism and Inhibits Angiogenesis
Suppression of ANGPTL4 Reprograms Endothelial Cell Metabolism and Inhibits Angiogenesis
PRJNA869060 | ENA
GenomicsANGPTL4 suppress clear cell renal cell carcinoma via inhibition lysosomal acid lipase
ANGPTL4 suppress clear cell renal cell carcinoma via inhibition lysosomal acid lipase
PRJNA1140650 | ENA
UnknownCharacterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice.
Not available
S-EPMC6795085 | biostudies-literature
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
GenomicsGDF-11 stimulates human extravillous trophoblast cell invasion by upregulating ANGPTL4 expression
GDF-11 stimulates human extravillous trophoblast cell invasion by upregulating ANGPTL4 expression
PRJNA1308547 | ENA
TranscriptomicsComparative expression data between ANGPTL4+/+ and ANGPTL4-/- mice whole colon tissue during DSS or SA-induced inflammation.
Protracted inflammatory responses are signatures common to many gastrointestinal disorders. Severe and chronic disorders often bring about extensive tissue damage, in turn leading to hypercytokinemia. Here, we show that stimuli like dextran sulphate sodium salt (DSS) and stearic acid (SA) cause acut...
ORGANISM(S): Mus musculus 
2017-03-28 | GSE78500 | GEO
TranscriptomicsSuppression of ANGPTL4 Reprograms Endothelial Cell Metabolism and Inhibits Angiogenesis
Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated. Here, using endothelial-specific Angptl4 knock-out mice (Angptl4iEC), and transcriptomi...
ORGANISM(S): Homo sapiens 
2023-11-22 | GSE211128 | GEO
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