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TranscriptomicsEGI-1 cell line treated with Saracatinib vs EGI-1 cell line untreated; EGI-1 xenograft treated with Saracatinib vs EGI-1 untreated
Biliary tract carcinoma (BTC) has a poor prognosis due to limited treatment options. There is therefore urgent need to identify new targets and to design innovative therapeutic approaches. Among potential candidate molecules, we evaluated the non-receptor tyrosine kinase Src, observing promising ant...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-36622 | biostudies-arrayexpress
TranscriptomicsEvaluation of HIPK2-modulated genes in cancer cells.
HIPK2, a member of the homeodomain-interacting protein kinase family, is a transcriptional corepressor whose activity inhibits tumor progression and allows tumor cell apoptosis in response to chemotherapy. HIPK2 regulates the function of numerous molecules and its inhibition by siRNA, hypoxia or mut...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-31089 | biostudies-arrayexpress
TranscriptomicsPotent antitumor activity of Cabozantinib, a c-MET and VEGFR2 Inhibitor, in a Colorectal Cancer Patient-derived Tumor Explant Model
Anti-angiogenic therapy is commonly used for the treatment of CRC. Although patients derive some clinical benefit, treatment resistance inevitably occurs. The MET signaling pathway has been proposed to be a major contributor of resistance to anti-angiogenic therapy. MET is upregulated in response to...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-GEOD-60939 | biostudies-arrayexpress
UnknownCompartment-Specific Bioluminescence Imaging platform for the high-throughput evaluation of antitumor immune function.
Not available
S-EPMC3325048 | biostudies-literature
TranscriptomicsPmel CD8+ stim 1 vs. stim 2
Repeat experiments of CD8+ pmel effector cells following one and two rounds of restimulation
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2348 | biostudies-arrayexpress
UnknownEvaluation of the antitumor activity of dacomitinib in models of human bladder cancer.
Not available
S-EPMC3883970 | biostudies-literature
ProteomicsA Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture
Preparation of AMDs. 125 μM Ac4ManNAz were incubated with Raw 264.7 (~ 107 cells/dish) for 24, 48, and 72 h, followed by gentle washing with PBS or complete medium to produce Raw 264.7-Ac4ManNAz. Subsequently, Raw 264.7-Ac4ManNAz (~ 107 cells) were resuspended in PBS containing Alkynyl-Ce6(0.1 μM), ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-21 | PXD050063 | Pride
Mouse Antitumor immune Plasma membrane rupture 
ProteomicsA Cytotoxic T Cell Inspired Oncolytic Nanosystem Promotes Lytic Cell Death by Lipid Peroxidation And Elicits Antitumor Immune Responses
Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic cell death by several mechanisms. Moreover, a prolonged uncontrolled immune response conversely leads to T-cell exhaustion. Therefore, an oncolytic system capable of eliciting the immune response by dissolving...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-05 | PXD044912 | Pride
Lipid peroxidation Mouse Antitumor immune 
UnknownEvaluation of acute toxicity and in vitro antitumor activity of a novel doxorubicin-loaded folate-coated pH-sensitive liposome.
Not available
S-EPMC10720880 | biostudies-literature
UnknownDiscovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.
Not available
S-EPMC7832087 | biostudies-literature
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