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ProteomicsThe transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
Commitment to and completion of sexual development are essential for Toxoplasma gondii to produce oocysts in the intestine of the feline host. Understanding of the molecular mechanism responsible for sexual commitment is extremely limited due to the lack of model systems. Here, we show that the tran...
ORGANISM(S): Toxoplasma gondii ME49 
2023-12-20 | PXD043808 | Pride
Toxoplasma gondii  transcription factors  ap2xi-2  merogony  pre-sexual development 
GenomicsThe transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
PRJNA1044037 | ENA
UnknownThe transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony.
Not available
S-EPMC10817966 | biostudies-literature
UnknownAP2XII-1 and AP2XI-2 Suppress Schizogony Gene Expression in Toxoplasma gondii.
Not available
S-EPMC11122372 | biostudies-literature
GenomicsThe transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
Commitment to and completion of sexual development are essential for Toxoplasma gondii to produce oocysts in the intestine of the feline host. Understanding of the molecular mechanism responsible for sexual commitment is extremely limited due to the lack of model systems. Here, we show that the tran...
ORGANISM(S): Toxoplasma gondii 
2023-12-19 | GSE248448 | GEO
Genomics
CUT&Tag of AP2XI-2 and AP2XII-1
PRJNA990966 | ENA
ProteomicsMass spectrometry-based proteomic characterization of T. gondii AP2XI-2 and AP2XII-1 interactomes
Sexual reproduction of Toxoplasma gondii, which is restricted to the small intestine of felids, is sparsely documented in studies involving domestic cats, which also raises ethical concerns. Chromatin modifiers dictate the developmental fate of the parasite during its multistage life cycle, but thei...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2023-09-16 | PXD042658 | Pride
Interactomes Toxoplasma gondii Ap2 transcription factors Nanolc-ms/ms 
Genomics
RNA-seq of AP2XI-2 or AP2XII-1 depleted Toxoplasma gondii
PRJNA990465 | ENA
ProteomicsIn vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming
Sexual reproduction of Toxoplasma gondii, which is restricted to the small intestine of felids, is sparsely documented in studies involving domestic cats, which also raises ethical concerns. Chromatin modifiers dictate the developmental fate of the parasite during its multistage life cycle, but thei...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2023-09-16 | PXD039400 | Pride
Merogony Toxoplasma gondii Sexual commitment Apetala Transcription factor Gene expression Nanolc-ms/ms Epigenetic Chromatin 
ProteomicsMass spectrometry-based proteomic characterization of TgGCN5b and TgGNAT2 interactomes
Histone acetylation, a fundamental epigenetic mechanism that controls gene activity, is essential for the developmental plasticity and virulence of the parasite Toxoplasma gondii. However, how this parasite organizes and deploys its acetyltransferase machinery has remained unclear. We show that T. g...
ORGANISM(S): Toxoplasma gondii Homo sapiens (Human) 
2026-07-25 | PXD079431 | Pride
Toxoplasma Acetylation Nanolc-ms/ms Interactome 
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