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TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
TranscriptomicsAstrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: novel insights from a mouse model
Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific expression of AEG-1 were challenged with N-nitrosodiethylamine (DEN) and developed multinodular HCC with steatotic features. Thus, we have identified the follwoing AEG-...
ORGANISM(S): Mus musculus 
2012-07-24 | E-GEOD-34669 | biostudies-arrayexpress
ProteomicsDephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression
This project includes raw mass spectrometry data supporting the identification of phosphorylation sites on AEG-1 (MTDH), particularly S426 and T492, in gastric cancer cells（BGC823） under CXCL12 treatment, as well as PPP1R21-interacting proteins including AEG-1 in HEK293T cells. This result supports ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-07 | PXD080675 | Pride
Gastric cancer  phosphorylation  astrocyte elevated gene-1  eukaryocytic translation initiation factor 4e  phosphotase protein 1 regulatory subunit 21  nuclear factor kappa b 
GenomicsAstrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Myeloid Cells Regulates Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Myeloid Cells Regulates Metabolic Dysfunction-Associated Steatohepatitis (MASH)
PRJNA1291791 | ENA
GenomicsAstrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Myeloid Cells Regulates Metabolic Dysfunction-Associated Steatohepatitis (MASH) [Spatial Transcriptomics]
Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Myeloid Cells Regulates Metabolic Dysfunction-Associated Steatohepatitis (MASH) [Spatial Transcriptomics]
PRJNA1292261 | ENA
GenomicsDissecting the Balance between Metabolic and Oncogenic Functions of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH)
Dissecting the Balance between Metabolic and Oncogenic Functions of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH)
PRJNA659367 | ENA
TranscriptomicsAstrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: novel insights from a mouse model
Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific expression of AEG-1 were challenged with N-nitrosodiethylamine (DEN) and developed multinodular HCC with steatotic features. Thus, we have identified the follwoing AEG-...
ORGANISM(S): Mus musculus 
2012-07-25 | GSE34669 | GEO
UnknownAstrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration.
Not available
S-EPMC3488579 | biostudies-literature
UnknownAstrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.
Not available
S-EPMC5982115 | biostudies-literature
UnknownAstrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.
Not available
S-EPMC2648696 | biostudies-literature
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