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GenomicsDiscovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically detectable as nucleosome-depleted regions or accessi...
ORGANISM(S): Drosophila melanogaster 
2015-02-13 | E-GEOD-59078 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HepG2 cells
ATAC-seq open chromatin maps for HepG2 cells (3 biological replicates), a liver model.
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7543 | biostudies-arrayexpress
TranscriptomicsTime series ATAC-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
T-helper 1 responses are involved in the development of many autoimmune diseases such as Multiple sclerosis (MS). MS is a relapse remitting disease that eventually progresses to a progressive neurodegenerative disease. During pregnancy the relapse rate of MS is significantly reduced with peak reduct...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-10444 | biostudies-arrayexpress
GenomicsSAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers
Metazoan SAGA and ATAC are distinct multi-subunits complexes that share the same catalytic HAT subunit (GCN5 or PCAF). Here we show that these human HAT complexes are targeted to different genomic loci representing functionally distinct regulatory elements both at broadly expressed and tissue specif...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-31052 | biostudies-arrayexpress
TranscriptomicsSingle cell ATAC-seq of human peripheral blood mononuclear cells under resting and stimulated conditions
Single cell ATAC-seq of PBMC - resting and stimulated. Used for comparison to asses the capabilies of the five-prime sequencing method in the detection of cis-regulatory elements using SCAFE (see publication).
ORGANISM(S): Homo sapiens 
2021-04-13 | E-MTAB-10382 | biostudies-arrayexpress
TranscriptomicsATAC-seq of iPSC and human dermal fibroblasts
ATAC-seq of iPSC and human dermal fibroblasts, used to compare open chromatin and transcription signal.
ORGANISM(S): Homo sapiens 
2021-05-02 | E-MTAB-10381 | biostudies-arrayexpress
GenomicsThe landscape of accessible chromatin in mammalian pre-implantation embryos (ATAC-Seq)
In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation development. However, the global chromatin landscape and its dynamics in this period remain unexplored. Here we report a genome-wide map of accessib...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-66581 | biostudies-arrayexpress
TranscriptomicsATAC-seq of oesophageal adenocarcinoma cell line MFD-1
The open chromatin of new esophageal adenocarcinoma cell line MFD-1 has been profiled by ATAC-seq.
ORGANISM(S): Homo sapiens 
2018-04-06 | E-MTAB-6720 | biostudies-arrayexpress
GenomicsATAC-sequencing in control and Stag2 knockdown cells
We performed ATAC-sequencing in LSK cells (Lin(neg)/c-Kit(+)/Sca-1(+)) from shRNA mice carrying an shRNA for either Renilla or Stag2. ATAC-sequencing control (Renilla) and Stag2 knockdown cells.
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-72367 | biostudies-arrayexpress
GenomicsATAC-seq of Oesophageal Cell Lines
ATAC-seq in oesophageal cell lines, OE33 (OAC), FLO1 (OAC), HET1A (Normal)
ORGANISM(S): Homo sapiens 
2016-09-12 | E-MTAB-4209 | biostudies-arrayexpress
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