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ProteomicsKinase-catalyzed Biotinylation to Map Cell Signaling Pathways (K-BMAPS): Application to Epidermal Growth Factor Signaling
Cell signaling involves a network of protein-protein interactions and post-translational modifications that govern cellular responses to environmental cues. To understand and ultimately modulate these signaling pathways to confront disease, the complex web of proteins that becomes phosphorylated aft...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027529 | Pride
Cell signaling  kinase  atp analog  atp-biotin  proteomics  interactome 
ProteomicsKinase-catalyzed Biotinylation for Discovery and Validation of Substrates to Multi-specificity Kinases NME1 and NME2
Protein phosphorylation by kinases regulates mammalian cell functions, such as growth, division, and signal transduction. Among human kinases, NME1 and NME2 are associated with metastatic tumor suppression, but remain understudied due to the lack of tools to monitor their cellular substrates. In par...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051411 | Pride
Proteomics Histidine kinase Phosphorylation Nme Substrate specificity Atp-biotin Protein kinase 
TranscriptomicsTranscription profiling of S. cerevisiae to investigate formaldehyde as source of free-energy during growth on glucose
Previously, it has been demonstrated that formate can be utilized by Saccharomyces cerevisiae as additional energy source using cells grown in a glucose-limited chemostat. Here, we investigated utilization of formaldehyde as co-substrate. Since endogenous formaldehyde dehydrogenase activities were i...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-18 | E-GEOD-8902 | biostudies-arrayexpress
UnknownEffects of Biotin on survival, ensheathment, and ATP production by oligodendrocyte lineage cells in vitro.
Not available
S-EPMC7259710 | biostudies-literature
UnknownATP-dependent Conformational Changes Trigger Substrate Capture and Release by an ECF-type Biotin Transporter.
Not available
S-EPMC4505438 | biostudies-literature
UnknownCo-crystal structure of Helicobacter pylori biotin protein ligase with biotinyl-5-ATP.
Not available
S-EPMC11701928 | biostudies-literature
UnknownBiotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module.
Not available
S-EPMC1815280 | biostudies-literature
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
UnknownChitosan-assisted permeabilization of ATP-biotin for live cell kinase-catalyzed biotinylation.
Not available
S-EPMC6335084 | biostudies-literature
ProteomicsCapture, release, and identification of newly synthesized proteins for improved profiling of functional translatomes
Proteins undergoing active translation in proliferating K562 cells during a 2-hour time frame were labeled with O-propargyl-puromycin for subsequent click reaction with cleavable Dde biotin-azide. Following capture on streptavidin agarose resin, nascent polypeptides were released from the resin by t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-22 | MSV000089950 | MassIVE
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