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TranscriptomicsDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Dendritic cells (DCs) are crucial for sensing pathogens and triggering immune response. GM-CSF myeloid dendritic cells (GM-DCs) secrete several cytokines including IL-2 upon activation by pathogen associated molecular pattern (PAMP) ligands. DC IL-2 has been shown to be important for innate and adap...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-58120 | biostudies-arrayexpress
TranscriptomicsArginine utilization following mycobacteria infection in macrophages is dependent on autocrine-paracrine signaling
Nitric oxide (NO) produced by macrophages (MØs) is toxic to both host tissues and invading pathogens and its regulation is therefore essential to suppress host cytotoxicity. MØ arginase 1 (Arg1) inhibits NO production by competing with NO synthases for arginine, the common substrate of NO synthases ...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-22935 | biostudies-arrayexpress
ModelsRegan2022 - Mechanosensitive EMT model with autocrine TGFbeta signaling
This model is an expansion of the Regan2022 - Mechanosensitive EMT model (MODEL2208050001); it includes a TGFβ signaling module and autocrine signaling in mesenchymal cells. The expanded 150-node (630 link) modular model undergoes EMT triggered by biomechanical and growth signaling crosstalk, or by ...
2023-12-13 | MODEL2208050002 | BioModels
ProteomicsIdentification of Autocrine Growth Factors Secreted by CHO cells for Applications in Single Cell Cloning Media
To identify low abundance autocrine growth factors in CHO cell conditioned media, we utilized a label-free shotgun proteomics approach. CHO cell conditioned media were harvested from fed batch bioreactors and concentrated using methanol/chlorofrom precipitation. Proteins in the samples were then su...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-01-22 | PXD000214 | Pride
Secreted proteins Chinese hamster ovary cells Shotgun proteomics Autocrine growth factors 
TranscriptomicsThe gene expression analysis of paracrine/autocrine factors in patients with spermatogenetic failure compared to normal spermatogenesis
The role of paracrine/autocrine factors in inflammation, immune response and tumor development is well established. There is also an evidence that some of the cytokines there involved may participate in the regulation of the male gonads. However, their involvement in pathogenesis of male infertilit...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-45887 | biostudies-arrayexpress
GenomicsThe Role of Endothelial Autocrine NRG1/ERBB4 Signaling in Cardiac Remodeling
The Role of Endothelial Autocrine NRG1/ERBB4 Signaling in Cardiac Remodeling
PRJNA632924 | ENA
GenomicsPyMINEr Finds Gene and Autocrine/Paracrine Networks from Human Islet scRNAseq
PyMINEr Finds Gene and Autocrine/Paracrine Networks from Human Islet scRNAseq
PRJNA480045 | ENA
GenomicsAutocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
PRJNA1187467 | ENA
GenomicsmiRNA profiling of MCF7 autocrine hGH
MicroRNAs are widely expressed in the normal pubertal mammary gland and orchestrate mammary gland development by regulating cell proliferation, differentiation, apoptosis, and metabolism. Although human Growth hormone(hGH) plays fundamental roles in normal mammary gland development and elevated auto...
ORGANISM(S): Homo sapiens 
2014-12-31 | GSE58845 | GEO
UnknownEzrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma.
Not available
S-EPMC5814345 | biostudies-literature
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