axin scaffold protein

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Lee2003 - Roles of APC and Axin in Wnt Pathway (without regulatory loop)

Lee2003 - Roles of APC and Axin in Wnt Pathway (without regulatory loop) This model is described in the article: The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. PLoS B...

2024-09-02 | BIOMD0000000658 | BioModels

Wnt signalosome assembly is governed by conformational flexibility of Axin and AP2 clathrin adaptor

Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic resonance spectroscopy to identify the membrane-proximal PPPSPxS motif an...

ORGANISM(S): Xenopus laevis (African clawed frog)

2025-04-30 | PXD061649 | Pride