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ProteomicsProNGF elicits retrograde axonal degeneration of basal forebrain neurons via p75NTR and induction of APP
Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple targets in the brain to regulate cognitive functions, and are compromised in numerous neurodegenerative disorders. Our previous study showed that injury to the target region of these neurons affects their viability in vi...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD043846 | Pride
Key words: proneurotrophin Axon degeneration P75ntr Axonal protein synthesis 
ProteomicsInhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo and modulates differential splicing
Several traumatic and neurodegenerative disorders of the CNS show axonal degeneration as a key and early pathological feature. Following a focal axonal lesion, an extended axonal disintegration by acute axonal degeneration (AAD) occurs within several hours. During AAD, activation of autophagic prote...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-04-30 | PXD011862 | Pride
Autophagy/ axonal degeneration/ ulk1/ spinal cord/ optic nerve/ splicing 
GenomicsLoss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
PRJNA1180930 | ENA
GenomicsInhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo and modulates differential splicing
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo and modulates differential splicing
PRJNA509593 | ENA
GenomicsMyelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
PRJNA917553 | ENA
TranscriptomicsLoss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
Axonal degeneration is a core feature of ischemic brain injury that limits functional recovery. The pro-degenerative molecule Sarm1 is required for Wallerian axon degeneration after traumatic and chemotoxic nerve injuries, however it is unclear if a similar mechanism mediates axonal degradation afte...
ORGANISM(S): Mus musculus 
2025-05-01 | GSE280862 | GEO
GenomicsRestoring Mitofusin balance in the nervous system prevents axonal degeneration in a CMT2A mouse model
Restoring Mitofusin balance in the nervous system prevents axonal degeneration in a CMT2A mouse model
PRJNA480457 | ENA
TranscriptomicsTimecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.
Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthes...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress
UnknownFOXO protects against age-progressive axonal degeneration.
Not available
S-EPMC5771393 | biostudies-literature
TranscriptomicsInhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo and modulates differential splicing
Several traumatic and neurodegenerative disorders of the CNS show axonal degeneration as a key and early pathological feature. Following a focal axonal lesion, an extended axonal disintegration by acute axonal degeneration (AAD) occurs within several hours. During AAD, activation of autophagic prote...
ORGANISM(S): Rattus norvegicus 
2020-09-23 | GSE123687 | GEO
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