b-ap15 - OmicsDI

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Mass Spectrometry (5)
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Mass spectrometry (1)
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Instrument Platform

Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2011 (2)
2018 (2)
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2020 (1)

CHEBI ID

CHEBI:30933 (1)
CHEBI:88572 (1)
CHEBI:184926 (1)
CHEBI:84549 (1)
CHEBI:170340 (1)
CHEBI:197368 (1)
CHEBI:197369 (1)
CHEBI:185779 (1)
CHEBI:172762 (1)
CHEBI:135821 (1)
CHEBI:180757 (1)
CHEBI:27423 (1)
CHEBI:159174 (1)
CHEBI:16214 (1)
CHEBI:160004 (1)
CHEBI:173286 (1)
CHEBI:185983 (1)
CHEBI:158820 (1)
CHEBI:196609 (1)
CHEBI:138026 (1)
CHEBI:164479 (1)
CHEBI:158854 (1)
CHEBI:165804 (1)
CHEBI:163500 (1)
CHEBI:20096 (1)
CHEBI:174796 (1)
CHEBI:173157 (1)
CHEBI:196525 (1)
CHEBI:71052 (1)
CHEBI:169897 (1)

Metabolite Name

Phosphohydroxypyruvic acid (1)
PI(18:0/20:4(8Z,11Z,14Z,17Z)) (1)
PE(18:4(6Z,9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (1)
PE(16:0/22:4(7Z,10Z,13Z,16Z)) (1)
PE(18:3(6Z,9Z,12Z)/P-18:1(9Z)) (1)
N-(tricosanoyl)-tetradecasphing-4-enine-1-phosphoethanolamine (1)
Pteropterin (1)
4-Keto-4'-hydroxyalloxanthin (1)
Saringosterol 3-glucoside (1)
Tocopherol succinate (1)
Tangeraxanthin (1)
D-Glucosyldihydrosphingosine (1)
Arg Met His (1)
Dolichyl phosphate (1)
Lys His Met (1)
Beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose (1)
12alpha-Hydroxy-3,7-dioxo-5beta-cholan-24-oic Acid (1)
Arg Asp Leu (1)
3beta-Hydroxy-6-oxo-5a-cholan-24-oic Acid (1)
17beta-Hydroxy-5a-androstan-3-one sulfate (1)
His Gly Gln (1)
Arg Cys Gly (1)
11,12,13-trihydroxy-9-octadecenoic acid (1)
Gly Asn His (1)
Myrsinone (1)
8-hydroxy-17-octadecene-9,11-diynoic acid (1)
5E,12Z-Otadecadienoic acid (1)
C16 Sphingosine (1)
1-(1-Propenylthio)propyl propyl disulfide (1)
2-Succinylbenzoate (1)

First Public Date

2022 (1)
2021 (1)
2014 (1)

Study type

Transcription profiling by array (1)

Release Date

2022 (5)
2019 (5)
2020 (3)
2015 (3)
2025 (2)
2023 (2)
2018 (2)
2017 (2)
2011 (1)
2024 (1)
2021 (1)
2016 (1)
2014 (1)
2013 (1)

Lab affiliation

Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17177, Sweden. Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow 119146, Russia. (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU) (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU) (1)
Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK (1)
Proteomics Center, Erasmus MC, Rottterdam (1)

Tags

xref:PubMed:22057347 (1)
xref:PubMed:35530310 (1)

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b-AP15, a novel proteasome inhibitor

Microarray based mRNA profiling was used to identify the mechanism of action for the small molecule b-AP15. MCF7 cells were treated with b-AP15 (1µM) or vehicle for 6 hours, followed by RNA isolation and gene expression analysis.

ORGANISM(S): Homo sapiens

2011-10-16 | E-GEOD-24150 | biostudies-arrayexpress

b-AP15, a novel proteasome inhibitor

Microarray based mRNA profiling was used to identify the mechanism of action for the small molecule b-AP15.

ORGANISM(S): Homo sapiens

2011-10-17 | GSE24150 | GEO

Homo sapiens

b-AP15, a novel proteasome inhibitor

PRJNA130031 | ENA

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5.

Not available

S-EPMC5556018 | biostudies-literature