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ProteomicsEfficient checkpoint signaling depends on the integrated activities of Bub1 and the RZZ complex
Kinetochore localized Mad1 is essential for generating a “wait anaphase” signal during mitosis hereby ensuring accurate chromosome segregation. Inconsistent models for the function and quantitative contribution of the two mammalian Mad1 kinetochore receptors: Bub1 and the Rod-Zwilch-ZW10 (RZZ) compl...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD012235 | Pride
Mitosis proteomics bub1 
ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
GenomicsBub1 negatively regulates osteoclast activation through NF-κB suppression in inflammatory arthritis
Bub1 negatively regulates osteoclast activation through NF-κB suppression in inflammatory arthritis
PRJNA1008093 | ENA
GenomicsTarget BUB1 kinase as a therapeutic strategy for inhibiting STAT3 signal pathway in Bladder cancer
Target BUB1 kinase as a therapeutic strategy for inhibiting STAT3 signal pathway in Bladder cancer
PRJNA534083 | ENA
ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
GenomicsGenome-wide CRISPR Screen Identifies BUB1 Kinase as a Druggable Vulnerability in Malignant Pleural Mesothelioma
Genome-wide CRISPR Screen Identifies BUB1 Kinase as a Druggable Vulnerability in Malignant Pleural Mesothelioma
PRJNA1240315 | ENA
TranscriptomicsTarget BUB1 kinase as a therapeutic strategy for inhibiting STAT3 signal pathway in Bladder cancer
The incidence for bladder urothelial carcinoma (UC), a common malignancy of the urinary tract, is about three times higher in men than in women. High expression of the mitotic kinase BUB1 is associated with a subset of human cancers, but how BUB1 drive Bladder tumorigenesis mechanism was unknown. Us...
ORGANISM(S): Homo sapiens 
2021-12-08 | GSE130145 | GEO
GenomicsBub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
PRJNA758021 | ENA
TranscriptomicsBub1 negatively regulates osteoclast activation through NF-κB suppression in inflammatory arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovitis and, bone and cartilage destruction. Although disease-modifying anti-rheumatic drugs (DMARDs) have dramatically improved clinical outcomes, these therapies are not universally effective in all patients due to ...
ORGANISM(S): Mus musculus 
2024-04-12 | GSE241409 | GEO
UnknownPhosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation.
Not available
S-EPMC10805674 | biostudies-literature
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