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ProteomicsCharacterization of novel a-Mangostin and Paeonol derivatives with cancer-selective cytotoxicity
a-Mangostin and Paeonol have shown anti-cancer and anti-inflammatory properties, however these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024999 | Pride
Colorectal cancer  anti-cancer drugs  cancer-selective compounds  natural compound derivatives  colon cancer organoids  paeonol  a-mangostin 
TranscriptomicsTranscriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer
In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxi...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-35428 | biostudies-arrayexpress
MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
GenomicsCharacterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 2)
Characterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 2)
PRJNA647379 | ENA
GenomicsCharacterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 1)
Characterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 1)
PRJNA647380 | ENA
GenomicsCharacterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 3)
Characterization of novel natural compound derivatives with cancer-selective cytotoxicity (RNA-seq dataset 3)
PRJNA647381 | ENA
TranscriptomicsTranscription profiling of human HMLER breast cancer cells treated with paclitaxel and salinomycin-treated HMLER breast cancer cells
Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. W...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-17215 | biostudies-arrayexpress
ProteomicsSelective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer
Clinical resistance such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) restrict the second-generation antiandrogens benefit in patients with castration-resistant prostate cancer (CRPC). Several strategies have been implemented to develop novel antiandrogens to ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035721 | Pride
Human prostate cancer cell 4d-label free proteomic analysis Lncap 
UnknownIdentification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer.
Not available
S-EPMC4707107 | biostudies-literature
GenomicsRational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer
Rational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer
PRJNA950400 | ENA
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