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MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
ProteomicsEndogenous cathelicidin protects against Toxoplasma gondii- associated liver damage
Toxoplasmosis, a disease caused by apicomplexan Toxoplasma gondii, is associated with various neuropsychiatric and behavioural conditions. Toxoplasmosis can cause serious complications for those with weakened immune systems and during pregnancy. Cathelicidins, peptides with antimicrobial and immunom...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-19 | PXD062489 | Pride
Cathelicidin  toxoplasma gondii  liver  brain. 
GenomicsInvestigation into the effect of cathelicidin on autoimmune CD4+ T cells
Investigation into the effect of cathelicidin on autoimmune CD4+ T cells
PRJNA779860 | ENA
ProteomicsCathelicidin deficiency disrupts goblet cell mucus secretion but not mucus associated proteins in Citrobacter rodentium-induced colitis
Colonic goblet cells respond to invading enteropathogens by secreting Muc2 mucin and other specific goblet cell proteins that physically entrap and expel microbes away from the epithelium. At present, it is unclear how innate effectors in the gut, including small cationic cathelicidin peptides secre...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-04 | PXD041957 | Pride
Colonic epithelium  cathelicidin  goblet cells  mucus  citrobacter rodentium  reactive oxygen species 
TranscriptomicsInvestigation into the effect of cathelicidin on autoimmune CD4+ T cells
We have shown that, in acute models of vaccination, the antimicrobial peptide cathelicidin potentiates Th17 cell differentiation. TO examine this in long-term, chronic inflammation, here we studied T cells in the mouse model of Multiple Sclerosis. We examined T cells from wildtype mice and those lac...
ORGANISM(S): Mus musculus 
2021-11-14 | GSE188655 | GEO
TranscriptomicsHuman cathelicidin antimicrobial peptide LL37 effect on human neonatal epidermal keratinocytes (NHEKs).
Analysis of undifferentiated keratinocytes or differentiated keratinocytes stimulated with or without human cathelicidin antimicrobial peptide (CAMP) LL37. Results provide insight into the biological effects of CAMP on human keratinocytes. NHEKs were divided into two groups; low calcium (0.05 mM) an...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-49472 | biostudies-arrayexpress
OtherThe effect of mouse cathelicidin (mCRAMP) on gene expression in CD4+ T cells cultured under Th17-driving conditions
We have shown that cathelicidin amplifies Th17 differentiation. To determine the mechanism through which this host defence peptide acts, we performed multiplex gene expression analysis (NanoString) to identify the effects of mouse cathelicidin (mCRAMP) on murine CD4+ T cells cultured under Th17-driv...
ORGANISM(S): Mus musculus 
2020-11-04 | GSE160757 | GEO
GenomicsCoturnix japonica
Analysis of cathelicidin cluster by Coturnix japonica.
PRJDB4591 | ENA
TranscriptomicsHuman cathelicidin antimicrobial peptide LL37 effect on human neonatal epidermal keratinocytes (NHEKs).
Analysis of undifferentiated keratinocytes or differentiated keratinocytes stimulated with or without human cathelicidin antimicrobial peptide (CAMP) LL37. Results provide insight into the biological effects of CAMP on human keratinocytes.
ORGANISM(S): Homo sapiens 
2014-08-01 | GSE49472 | GEO
UnknownThe neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation.
Not available
S-EPMC7904761 | biostudies-literature
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