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MetabolomicsMulti-omics-identified StAPR3 enhances potato Cd tolerance and tuber quality via sulfur metabolism and glutathione redox homeostasis

Cadmium (Cd) in agricultural soils inhibits potato growth, disrupts tuber development, and causes Cd accumulation in edible tubers, threatening food safety. Here, we determined the EC50 of Cd in potato, which induced oxidative stress and chloroplast damage. Transcriptomic and metabolomic co-analy...

2026-09-04 | MTBLS15532 | MetaboLights
TranscriptomicsIFN-γ Upregulates Survivin and Ifi202 Expression to Induce Survival and Proliferation of Tumor-Specific T Cells
Transcriptional profiling of mouse tumor-specific cytotoxic T lymphocytes (CTL) comparing activation-induced gene expression profiles induced by tumor-specific antigen (Ag) and CD3 mAb. CTLs were stimulated with either Ag or CD3 mAb for 3 and 24 h, respectively. The stimulated CTLs were compared to ...
ORGANISM(S): Mus musculus 
2010-12-03 | E-GEOD-22890 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Parp-1 deficient and wild type T cells following CD3 and CD3/CD28 activation
Primary T cells were isolated from spleen of Parp-1-/- and wild-type mice by magnetic depletion of non-T cells using a MACS Pan-T Cell isolation kit, according to the manufacturer´s instruction (Mintenyi Biotec, Bergisch Gladbach, Germany). Purity was assessed by flow cytometry analysis using antibo...
ORGANISM(S): Mus musculus 
2008-08-04 | E-MEXP-1237 | biostudies-arrayexpress
TranscriptomicsAcquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
Genomic aberrations are of predominant importance to the biology and clinical outcome of patients with chronic lymphocytic leukemia (CLL), and FISH-based genomic risk classifications are routinely used in clinical decision making in CLL. One of the known limitations of CLL FISH is the inability to ...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-30777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Itk-deficient CD3+, CD4+ and CD8+ T-cells
This SuperSeries is composed of the following subset Series:; GSE12464: Transcriptional signatures of Itk-deficiency using CD3+ T-cells; GSE12465: Transcriptional signatures of Itk-deficiency using CD3+, CD4+ and CD8+ T-cells Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2009-05-29 | E-GEOD-12466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse eGFP/CD3-double positive splenocytes to identify imprinted genes expressed in adult CD3+ splenocytes
Identification of imprinted genes expressed in adult CD3+ splenocytes Experiment Overall Design: For analysis of imprinted gene expression of uniparental-derived cells in adult recipients we chose eGFP/CD3-double positive splenocytes as a defined cell type, and first identified imprinted genes that ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6757 | biostudies-arrayexpress
TranscriptomicsComparison of intestinal surface CD3- refractory celiac disease type II (RCDII) cell lines with intestinal surface CD3+ cell lines of non-RCDII patients
Analysis of transcriptional differences between aberrant (surface CD3-) RCDII cell lines and regular (surface CD3+) intraepithelial cell lines in order to characterize aberrant RCDII cells. All cell lines were cultured from duodenal biopsies of RCDII or non-RCDII (either celiac or non-celiac) patien...
ORGANISM(S): Homo sapiens 
2012-06-11 | E-GEOD-33078 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Itk-deficienct CD3+, CD4+ and CD8+ T cells
The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3+ T-cells, including CD4+ and CD8+ subsets, using Affymetrix microarrays. The lar...
ORGANISM(S): Mus musculus 
2009-05-29 | E-GEOD-12465 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of healthy human CD4+ cells after CD3 and CD28 stimulation
Genome-wide DNA methylation reference profiles of CD4+ cells after CD3 and CD28 stimulation in two healthy human individuals using the MeDIP technique a custom oligonucleotide array targetting the vast majority of annotated TSSs and non-promoter CGIs in the human genome.
ORGANISM(S): Homo sapiens 
2010-03-23 | E-MTAB-207 | biostudies-arrayexpress
ProteomicsThe resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex
The T-cell receptor (TCR) initiates T-lymphocyte activation, but the mechanism of TCR activation remains uncertain. Here, we present cryogenic electron microscopy structures for the unliganded and human leukocyte antigen (HLA)-bound human TCR–CD3 complex in nanodiscs that provide a native-like lipid...
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD070648 | Pride
Tcr2 Disulfide bridge Membrane 
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