cd8+ t cells - OmicsDI

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UNIPROT ID/AC

Q0GK43 (1)
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CHEBI ID

CHEBI:17203 (3)
CHEBI:17196 (3)
CHEBI:15428 (3)
CHEBI:15891 (3)
CHEBI:16704 (3)
CHEBI:17268 (3)
CHEBI:16737 (3)
CHEBI:17490 (3)
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CHEBI:3899 (2)
CHEBI:85805 (2)
CHEBI:15622 (2)
CHEBI:28748 (1)

Metabolite Name

Betaine (5)
Guanine (5)
L-Tryptophan (5)
Xanthine (5)
Creatinine (5)
Hypoxanthine (5)
N6-Methyladenosine (4)
Linoleamide (4)
1-Methylguanosine (4)
5'-Methylthioadenosine (4)
Norepinephrine (4)
D-Ornithine (4)
L-Threonine (4)
Adenosine (4)
Spermidine (4)
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Xanthosine (4)
Guanosine (4)
Creatine (4)
L-Methionine (4)
L-Tyrosine (4)
1-Methyladenosine (4)
N-Methyl-1-deoxynojirimycin (3)
D-Fructose (3)
2'-Deoxyadenosine (3)
Maltol (3)
Hypotaurine (3)
Thiamine monophosphate (3)
L-Alanine (3)
Didanosine (3)

First Public Date

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Modelling Approach

Ordinary differential equation model (23)
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Study status

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Lab affiliation

Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (10)
University of Oxford (7)
Institute of Pharmacology and Structural Biology, CNRS, Toulouse, France (5)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (4)
Massachusetts Institute of Technology (4)
Department of Pathology, Dalhousie University (3)
Deputy Head (Research), Department of Biochemistry and Molecular Biology Head Immunoproteomics Laboratory Infection and Immunity Program Room 214, level 2, 15 Innovation Walk Monash Biomedicine Discovery Institute Monash University, Clayton Campus Clayton 3800 Victoria Australia (3)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (3)
Infection and Immunity Program, Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia (3)
School of Life Sciences, University of Dundee, Dundee, UK (3)
University of Oxford University of Dundee (3)
Army Medical University (Third Military Medical University) (2)
Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, CB2 0XY, UK (2)
Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (2)
Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421 Homburg, Germany (2)
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA (2)
Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany (2)
Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany (2)
Dept. Oncology-Pathology, Scilifelab, Karolinska Institutet, Sweden (2)
Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA (2)
Indian Institute of Science Bengaluru (2)
Institute of Pharmacology and Structural Biology, CNRS, Toulouse (2)
Qilu Hospital of Shandong University (2)
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China (2)
Systems Inflammation group, Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Norway (2)
University of Dundee (2)
1 Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, PR China 2 Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200049, PR China 3 Clinical Translation Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China. (1)
1. Proteomics Facility, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands; 2. Biomolecular Mass Spectrometry and Proteomics, Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, the Netherlands (1)
1.Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, USA. 2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA. (1)
225, Veterinary Medical Center University of Minnesota 1365, Gortner Avenue St. Paul, MN 55108 (1)

Keyword

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Relapse (1)

IsPrivate

False (27)

Submitter Keywords

Immuno-oncology (17)
Not Peer Reviewed (1)

Classification

viruses (3)

Study type

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Differential (2)
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Location

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Metabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights

Extracellular metabolome of activated CD8+ T cells

Not available

ORGANISM(S): Mus musculus

ST002373 | MetabolomicsWorkbench

Metabolite assay of T cells that are antigen-specially activated by viscoelastic synthetic antigen presenting cells

Adoptive T cell receptor (TCR)–based immunotherapy offers a powerful strategy to target solid tumors. However, the physical properties of the antigen-presenting interface regulate T cell metabolic programming remains poorly defined. Here we develop synthetic viscoelastic activating cells (SynVAC)...

2026-09-03 | MTBLS15444 | MetaboLights

[U-13C]glucose tracing in naïve vs. activated CD8+ T cells

Not available

ORGANISM(S): Mus musculus

ST002362 | MetabolomicsWorkbench

Metabolomics analysis of WT vs. GOT1 knockout CD8+ T cells

Not available

ORGANISM(S): Mus musculus

ST002374 | MetabolomicsWorkbench

Targeting CRBN to alter CD8 T cell metabolism

Not available

ORGANISM(S): Mus musculus