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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
ProteomicsPeripheral Blood CD8+ T-Lymphocyte Immune Response in Benign and Subpopulations of Breast Cancer Patients
Peripheral blood CD8+ T-lymphocytes play a crucial role in cell-mediated immunity and tumour-related immune responses in breast cancer. The protein profile analysis of CD8+ T-lymphocytes in benign, Luminal A, Luminal B and triple-negative breast cancer (TNBC) patients in comparison to healthy contro...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD051985 | Pride
Breast cancer  cd8+ t-lymphocytes  rna degradation  granzymes 
TranscriptomicsTranscription profiling of human CD8 T lymphocytes from two healthy donors transduced with hTERT
Expression in GFP vs. GFP/hTERT transduced CD8 T Lymphocytes from Healty Donors (HD) 1 and 2 at early and late passages. Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were p...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5144 | biostudies-arrayexpress
TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
TranscriptomicsEarly specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses
T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combine single-cell gene expression analyses with...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54321 | biostudies-arrayexpress
TranscriptomicsMurine CD8+ T cells: in vitro-derived vs. thymocytes
Transcriptional profiling of mouse in-vitro derived CD8+ cells (obtained after culturing BM-HSCs isolated from B6 mice) with OP9-DL1 cells for 35 days were compared to CD8+ thymocytes isolated from 4-5 weeks old B6 mice. Our goal was to determine similarities and differences in gene expression prof...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37669 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD300a+ CD8+ T lymphocytes
The purpose of this microarray study is to characterize molecular and functional differences between CD4+CD300a+ vs CD4+CD300a- T lymphocytes, and between CD8+CD300a+ vs CD8+CD300a- T lymphocytes, respectively.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-TABM-902 | biostudies-arrayexpress
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
TranscriptomicsTranscription profiling of human CMV-stimulated CD69+, hCMV-stimulated CD69- and unstimulated monoclonal CD4+ T-LGL lymphocytes from peripheral blood samples from four TCRVbeta+/CD4+ T-LGL lymphocytosis patients
Recent studies suggest the potential involvement of common antigenic stimuli on the ontogeny of monoclonal TCRalphabeta+/CD4+/NKa+/CD8-/+dim T-large granular lymphocyte (LGL) lymphocytosis. Since healthy individuals show (oligo)clonal expansions of hCMV-specific TCRVbeta+/CD4+/cytotoxic/memory T-cel...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12488 | biostudies-arrayexpress
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, effe...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-04 | PXD001065 | Pride
Murine Cd8+ Lc-ms/ms 
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