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TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
ProteomicsProteomic analysis of purified human centrosomes
Identification and comparison of protein content of 2 independently prepared fractions of human centrosomes.
ORGANISM(S): Homo sapiens (Human) 
2015-12-16 | PXD003226 | Pride
Human centrosomes Nanolc-ms/ms 
ProteomicsProteomic analysis of purified human centrosomes
Identification and comparison of protein content of 2 independently prepared fractions of human centrosomes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080747 | MassIVE
GenomicsExtra centrosomes delay DNA damage-driven tumorigenesis
Extra centrosomes delay DNA damage-driven tumorigenesis
PRJEB72005 | ENA
GenomicsExtra centrosomes induce PIDD1-mediated inflammation and Immunosurveillance
Extra centrosomes induce PIDD1-mediated inflammation and Immunosurveillance
PRJNA984619 | ENA
TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
ProteomicsProteomic profiling of centrosomes across multiple cell and tissue types by a new affinity capture method
Centrosomes are small cytoplasmic organelles that play fundamental roles in a range of cellular processes. Nearly all vertebrate cell types contain centrosomes, but whether centrosome composition and function differ between cell types, tissues and pathologies remains an outstanding question. Until n...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-10-18 | PXD040308 | Pride
Proteomics Capture peptide Capture-ms Centrosomes 
TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | GSE35240 | GEO
ProteomicsProteomic profiling of centrosomes across multiple cell and tissue types by a new affinity capture method
Centrosomes are small cytoplasmic organelles that play fundamental roles in a range of cellular processes. Nearly all vertebrate cell types contain centrosomes, but whether centrosome composition and function differ between cell types, tissues and pathologies remains an outstanding question. Until n...
ORGANISM(S): Homo sapiens (Human) 
2023-10-18 | PXD040309 | Pride
Proteomics Centrosomes Capture ms 
TranscriptomicsExtra centrosomes induce PIDD1-mediated inflammation and Immunosurveillance
Unscheduled increases in cellular ploidy underlie defects in tissue function, premature aging, and malignancy. A concomitant event to polyploidization is the amplification of centrosomes, the main microtubule organization center in animal cells. Supernumerary centrosomes are frequent in tumors, corr...
ORGANISM(S): Mus musculus 
2023-08-21 | GSE235120 | GEO
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