ceramidase - OmicsDI

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Unknown (245)
Genomics (28)
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Organisms

Homo sapiens (10)
Mus musculus (8)
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Tissue

Blood plasma (1)
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Disease

Commensal bacterial infectious disease (1)
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Technology Type

Mass spectrometry (12)
Mass Spectrometry (5)
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Mass spectrometry assay (3)

Instrument Platform

Liquid Chromatography MS - positive - reverse phase (5)
Liquid Chromatography MS - negative - reverse phase (4)
QExactive negative (Thermo Scientific) (2)
QExactive positive (Thermo Scientific) (2)
QTOF G6550A negative (Agilent) (2)
QTOF G6550A positive (Agilent) (2)
QTRAP 6500 negative (AB Sciex) (2)
QTRAP 6500 positive (AB Sciex) (2)
Orbitrap elite negative (Thermo Scientific) (2)
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Liquid Chromatography MS - negative - hilic (2)
Liquid Chromatography MS - positive - hilic (2)
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Orbitrap velos HCD negative (Thermo Scientific) (1)
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QTRAP 4000 (AB Sciex) (1)
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QTRAP 4000 -50 (AB Sciex) (1)
QTRAP 4000 -45 (AB Sciex) (1)
QTRAP 4000 -40 (AB Sciex) (1)
QTRAP 4000 -30 (AB Sciex) (1)

Publication Date

2023 (10)
2017 (8)
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2024 (5)
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2014 (3)
2022 (3)
2015 (2)
2020 (2)
2013 (1)
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2018 (1)

CHEBI ID

CHEBI:88901 (1)
CHEBI:86427 (1)
CHEBI:89239 (1)
CHEBI:190675 (1)
CHEBI:190674 (1)
CHEBI:190202 (1)
CHEBI:187848 (1)
CHEBI:53753 (1)
CHEBI:88875 (1)
CHEBI:90051 (1)
CHEBI:183968 (1)
CHEBI:178963 (1)
CHEBI:183801 (1)
CHEBI:89759 (1)
CHEBI:171310 (1)
CHEBI:90053 (1)
CHEBI:85427 (1)
CHEBI:84419 (1)
CHEBI:191866 (1)
CHEBI:191864 (1)
CHEBI:89237 (1)
CHEBI:144339 (1)
CHEBI:176734 (1)
CHEBI:89198 (1)
CHEBI:77127 (1)
CHEBI:90066 (1)
CHEBI:142699 (1)
CHEBI:183132 (1)
CHEBI:131427 (1)
CHEBI:142701 (1)

Metabolite Name

LPC 13:0|LPC 13:0|LPC 13:0|LPC 13:0|LPC 13:0 (3)
LPE 18:0|LPE 18:0|LPE 18:0|LPE 18:0|LPE 18:0 (3)
PC 18:0/18:2|PC 18:0/18:2|PC 18:0/18:2|PC 18:0/18:2|PC 18:0/18:2 (3)
PC 14:0/18:0|PC 14:0/18:0|PC 14:0/18:0|PC 14:0/18:0|PC 14:0/18:0 (3)
PG 18:0/18:2|PG 18:0/18:2|PG 18:0/18:2|PG 18:0/18:2|PG 18:0/18:2 (3)
Ethyl lysine (2)
Anandamide (18:3, n-3) (2)
Hex-3-enedioylcarnitine (2)
(-)-Norushinsunine (2)
24-epi-brassinolide (2)
Precocene I (2)
Alpha-Tocopherol phosphate (2)
5-Amino-1-[(2R,3R,4S,5R)-5-[(benzylamino)methyl]-3,4-dihydroxyoxolan-2-yl]imidazole-4-carboxamide (2)
4-Hydroxynonenal glutathione (2)
2-Ethylpropanedioylcarnitine (2)
Cbhcy (2)
(2E)-Hept-2-enedioylcarnitine (2)
N(epsilon)-(carboxyethyl)lysine (2)
1,2,3,4-Tetrahydro-6-propanoylpyridine (2)
5-Methylundecanoylcarnitine (2)
Cyclo(Pro-Leu) (2)
Enterolactone 3'-glucuronide (2)
Misoprostol acid (2)
Stepronin (2)
Pelrinone (2)
Triton X-100 (2)
Prenylcysteine (2)
2-Deoxy-D-glucopyranose 6-phosphate (2)
Dephospho-CoA (2)
Polyporusterone D (2)

First Public Date

2023 (7)
2024 (4)
2026 (3)
2025 (3)
2022 (3)
2020 (2)
2021 (1)
2015 (1)
2014 (1)

Study type

Transcription profiling by array (4)
Exome sequencing (1)

Release Date

2021 (31)
2023 (26)
2022 (25)
2018 (23)
2020 (19)
2024 (16)
2017 (15)
2015 (14)
2019 (14)
2016 (14)
2014 (9)
2025 (8)
2012 (8)
2011 (7)
2009 (5)
2013 (4)
2026 (4)
2008 (4)
2010 (2)
2006 (1)
2004 (1)

Lab affiliation

Assoc. Prof. Dr. Christian S. Lentz Associate Professor, Department of Medical Biology, UiT- The Arctic University of Norway, 9019 Tromsø, Norway (1)
Cardiovascular Biochemistry Group, Research Institute of the Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain (1)
Principal Scientist, Immunophysiology Laboratory, Animal Physiology Division, ICAR- National Dairy Research Institute, Karnal- 132001, Haryana, India (1)
Proteomics Facility, Centre for Drug Safety Science, Dept Molecular and Clinical Pharmacology, University of Liverpool (1)
University of Santiago de Compostela (1)

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Targeting the Ceramidase ACER3 Attenuates Cholestasis in Mice by Mitigating Bile Acid Overload via Unsaturated Ceramide-mediated LXRβ Signaling Transduction

In this work, we show that ACER3 expression is upregulated in cholestatic livers and positively correlates with the severity of CLI in patients. Targeting ACER3 increases CER(d18:1/18:1) in the cholestatic liver, which binds to LXRβ and activates its signaling transduction to enhance BA sulfation...

2025-02-17 | MTBLS12198 | MetaboLights

Acid ceramidase regulates innate immune memory

PRJNA779737 | ENA

Presence of ceramidase activity in electronegative LDL

Electronegative LDL (LDL(-)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them, LDL(-) has increased content of bioactive lipid mediators, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), w...

ORGANISM(S): Homo sapiens (Human)

2023-01-09 | PXD036168 | Pride

Acid ceramidase regulates innate immune memory

Innate immune memory, also called "trained immunity," is a metabolically and epigenetically regulated functional state of myeloid cells. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We found that exogenously administered sphingolipids an...

ORGANISM(S): Homo sapiens

2023-11-27 | GSE188641 | GEO

CDase is a pan-ceramidase in Drosophila.

Not available

S-EPMC3016975 | biostudies-literature

Acid ceramidase regulates innate immune memory.

Not available

S-EPMC11907240 | biostudies-literature

Cell-nonautonomous function of ceramidase in photoreceptor homeostasis.

Not available

S-EPMC2271043 | biostudies-literature

Molecular mechanism for sphingosine-induced Pseudomonas ceramidase expression through the transcriptional regulator SphR.