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ProteomicsOpportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P. gingivalis infection mediates therapeutic resistance via inhibiting lethal mitophagy in cancer cells and tumors. Mechanistically, ...
ORGANISM(S): Porphyromonas gingivalis Homo sapiens (Human) 
2024-06-23 | PXD051568 | Pride
Therapeutic resistance Oral cancers Ceramide  ceramide-dependent mitophagy  sphingolipid metabolism  oral infection  oral microbiota 
GenomicsMis-localized mitochondrial ribosomes guide ceramide-dependent mitophagy for inducing cell death via alterations of the bioenergetics and metabolism
Mis-localized mitochondrial ribosomes guide ceramide-dependent mitophagy for inducing cell death via alterations of the bioenergetics and metabolism
PRJNA757757 | ENA
UnknownHPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.
Not available
S-EPMC5538428 | biostudies-literature
OtherMis-localized mitochondrial ribosomes guide ceramide-dependent mitophagy for inducing cell death via alterations of the bioenergetics and metabolism
In this work, we set out experiments to determine the mechanisms that regulate mitochondrial trafficking of p17/PERMIT-CerS1 complex in response to Drp1 activation to induce mitophagy and cellular consequences of this process altering mitochondrial metabolism in cultured cells in situ and genetic mi...
ORGANISM(S): Homo sapiens 
2021-12-01 | GSE182781 | GEO
UnknownAging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.
Not available
S-EPMC8127241 | biostudies-literature
GenomicsAging stress and ceramide dependent RNA sequencing expression profiling depends on ceramide synthase 6
Aging stress and ceramide dependent RNA sequencing expression profiling depends on ceramide synthase 6
PRJNA624654 | ENA
UnknownAlterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects.
Not available
S-EPMC10577547 | biostudies-literature
UnknownOpportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors.
Not available
S-EPMC11108982 | biostudies-literature
TranscriptomicsEffects of fumarate on the metabolic reprogramming of aging T-cells associated with rescue of the T-cell anti-tumor functions
Changes in mitochondrial bioenergetics in aging T-cells play a key role in the decrease in T-cell function and tumor resistance with aging. The bioactive sphingolipid ceramide, induced by aging stress, is a major player in these changes, as its accumulation at the mitochondrial membranes of both mou...
ORGANISM(S): Mus musculus 
2025-06-09 | GSE247335 | GEO
UnknownAlzheimer's Disease-Associated Amyloid Beta Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Anti-Tumor Immunity.
Not available
S-EPMC12395851 | biostudies-literature
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