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ProteomicsViruses antagonise expression and function of cGAMP transporters, channels and pores
DNA sensing is a fundamental process in the immune system, including host defence against viruses. The DNA sensor cGAS synthesises 2’3’ cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which subsequently induces innate immunity. cGAMP not only activates STING in the cell where it is ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-15 | PXD043229 | Pride
Na sensing  cgamp  cgamp transport  vrac  lrrc8a  slc46a2  p2x7  herpes simplex virus  ul56 
TranscriptomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [T_cells_RNA_Seq]
STING agonists are promising innate immune therapies and can synergize with adaptive immune checkpoint blockade therapies for cancer treatment, but their effectiveness is limited by the toxicity to activated T cells. How STING agonists such as cGAMP and its analogs enter and induce STING activation ...
ORGANISM(S): Homo sapiens 
2026-05-21 | GSE325689 | GEO
TranscriptomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [U937_DOX_RNA_Seq]
STING agonists are promising innate immune therapies and can synergize with adaptive immune checkpoint blockade therapies for cancer treatment, but their effectiveness is limited by the toxicity to activated T cells. How STING agonists such as cGAMP and its analogs enter and induce STING activation ...
ORGANISM(S): Homo sapiens 
2026-05-21 | GSE325690 | GEO
GenomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [U937_DOX_RNA_Seq]
Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [U937_DOX_RNA_Seq]
PRJNA1441473 | ENA
GenomicsActivation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [T_cells_RNA_Seq]
Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [T_cells_RNA_Seq]
PRJNA1441475 | ENA
UnknownLRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.
Not available
S-EPMC12629894 | biostudies-literature
UnknownA protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels.
Not available
S-EPMC12828768 | biostudies-literature
UnknownABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Not available
S-EPMC12811381 | biostudies-literature
UnknowncGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia.
Not available
S-EPMC11871612 | biostudies-literature
UnknownPuromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport.
Not available
S-EPMC12698191 | biostudies-literature
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