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ModelsProctor2005 - Actions of chaperones and their role in ageing
Proctor2005 - Actions of chaperones and their role in ageing This model is described in the article: Modelling the actions of chaperones and their role in ageing. Proctor CJ, Soti C, Boys RJ, Gillespie CS, Shanley DP, Wilkinson DJ, Kirkwood TB. Mech. Ageing Dev. 2005 Jan; 126(...
2024-09-02 | BIOMD0000000091 | BioModels
ProteomicsThe landscape of molecular chaperones across human tissues reveals a layered architecture of core-variable chaperones
The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Through computational analyses of large-scale tissue transcriptomes, we unveiled t...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-08 | PXD022678 | Pride
Chaperones  aging  data integration  differentiation  protein quality control  protein misfolding diseases  proteostasis  systems biology  tissue specificity compression networks 
TranscriptomicsFACT and Spt6 Prevent Cryptic Transcription by Impeding H2A.Z Loading in Gene Bodies
H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here, we provide genomic and biochemical evidence...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-12 | E-GEOD-62880 | biostudies-arrayexpress
GenomicsHost chaperones can define the fitness of adaptive influenza variants
Host chaperones can define the fitness of adaptive influenza variants
PRJNA453534 | ENA
UnknownStructure-function relationship of H2A-H2B specific plant histone chaperones.
Not available
S-EPMC6985425 | biostudies-literature
GenomicsChIP-seq of H2A.Z and its histone chaperones during the cell cycle
The aim of this study was to uncover cell cycle dependent chromatin binding of H2A.Z and its histone chaperones. U2OS cells were stably transfected with Twin-Strep-tagged H2A.Z, ANP32e, or YL1 constructs, and WT cells were used as a negative/background control. U2OS cells were synchronised in G1 or ...
ORGANISM(S): Homo sapiens 
2023-06-29 | E-MTAB-11617 | biostudies-arrayexpress
GenomicsEssential histone chaperones collaborate to regulate transcription and chromatin integrity
Essential histone chaperones collaborate to regulate transcription and chromatin integrity
PRJNA674587 | ENA
UnknownThe human HSP70 family of chaperones: where do we stand?
Not available
S-EPMC4837186 | biostudies-literature
ProteomicsSmall heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harboring their own protein quality control factors. While the chaperones of the mitochondrial matrix have been well characterized, it is poorly understood which chaperones protect the mitochondrial intermembrane space. We show th...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD038275 | Pride
Charcot-marie-tooth (cmt) disease Protein quality control Intermembrane space Small heat shock proteins Mitochondria Chaperones 
GenomicsHistone chaperones ASF1s control germination by repressing PRX69
Histone chaperones ASF1s control germination by repressing PRX69
PRJNA1445214 | ENA
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