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ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063537 | Pride
Palmitoylation Senescence 
GenomicsTRIM15 drives chondrocyte senescence and osteoarthritis progression
TRIM15 drives chondrocyte senescence and osteoarthritis progression
PRJNA1184794 | ENA
GenomicsSirt6 attenuates chondrocyte senescence and osteoarthritis progression
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
PRJNA851254 | ENA
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063840 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063864 | Pride
Osteoarthritis Senescence 
TranscriptomicsTRIM15 drives chondrocyte senescence and osteoarthritis progression
Chondrocyte senescence underlies osteoarthritis (OA). However, the pathogenesis of chondrocyte senescence remains largely unclear. Here we report that TRIM15 is a critical regulator in chondrocyte senescence. TIRM15 is highly expressed in chondrocytes of senescent cartilage from human OA patients an...
ORGANISM(S): Homo sapiens 
2025-02-24 | GSE281609 | GEO
ProteomicsMYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is ne...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-07 | PXD044684 | Pride
Osteoarthritis  chondrocyte senescence  clathrin-mediated endocytosis  myosin light chain 3  notch signaling 
ProteomicsMatrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Cartilage aging is a quintessential feature of knee osteoarthritis, and extracellular matrix (ECM) stiffening is a typical feature of cartilage aging. However, the mechanism of ECM stiffening to influence chondrocytes and downstream molecules is still poorly understood. Here, we mimicked the physiol...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046993 | Pride
Cartilago articularis，matrix stiffness，osteoarthritis 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [II]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063859 | Pride
Osteoarthritis Il-1β 
TranscriptomicsSirt6 attenuates chondrocyte senescence and osteoarthritis progression
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
ORGANISM(S): Mus 
2022-11-29 | GSE206513 | GEO
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