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TranscriptomicsRNA-seq of choroid and retina in tree shrews with choroidal neovascularization
In order elucidate the key signaling pathways in choroidal neovascularization, we induced choroidal angiogenesis by laser photocoagulation in 12 tree shrews and obtained mRNA profiles of their choroids and retinas by high-throughput transcriptome sequencing. Gene ontology(GO) and kyoto encyclopedia ...
ORGANISM(S): Tupaia chinensis 
2021-03-21 | E-MTAB-10198 | biostudies-arrayexpress
ProteomicsProteotranscriptomic Analyses in Laser-Induced Choroidal Neovascularization
To probe into the molecular mechanism underlying the onset of choroidal neovascularization (CNV), integrated transcriptomic and proteomic analyses of the retinas in mice with laser-induced CNV were performed by using RNA sequencing and tandem mass tag.
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD039971 |
ProteomicsInsights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor
Previous studies on the biomarkers of pathologic myopia choroidal neovascularization (pmCNV) development merely detected limited types of proteins and provide a meagre illustration of the underlying pathways. Hence, an intact picture of molecular changes in the aqueous humor (AH) of pmCNV patients i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038430 | Pride
Proteomic  pathologic myopia  choroidal neovascularization  aqueous humor  gfap  biomarker. 
GenomicsRNA analysis of the circadian rhythm of choroidal neovascularization
RNA analysis of the circadian rhythm of choroidal neovascularization
PRJNA1067979 | ENA
ProteomicsLysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined. Here, we investigated the role of the endolysosomal cation channel, two-pore c...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD081711 | Pride
Choroidal vascular cell 
GenomicsYoung and aging mouse immune cells in laser-induced choroidal neovascularization
Young and aging mouse immune cells in laser-induced choroidal neovascularization
PRJNA1419125 | ENA
TranscriptomicsEndothelial cell heterogeneity in pathological angiogenesis characterized by metabolic transcriptome diversity
Endothelial cell (EC) metabolism regulates angiogenesis and is an emerging target for anti-angiogenic therapy in tumor and choroidal neovascularization (CNV). In contrast to tumor ECs (TECs), CNV-ECs cannot be isolated for unbiased metabolic target discovery. Here we used scRNA-sequencing to profile...
ORGANISM(S): Mus musculus 
2020-06-25 | E-MTAB-8119 | biostudies-arrayexpress
GenomicsRNA-seq of choroid and retina in tree shrews with choroidal neovascularization
RNA-seq of choroid and retina in tree shrews with choroidal neovascularization
PRJEB43598 | ENA
GenomicsMus musculus
Mice choroidal neovascularization sequencing
PRJNA721185 | ENA
GenomicsEndothelial TGFβ signaling regulates choroidal neovascularization severity via myeloid–endothelial interaction
Endothelial TGFβ signaling regulates choroidal neovascularization severity via myeloid–endothelial interaction
PRJNA1418721 | ENA
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