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GenomicsGene expression by RNAseq in bronchial biopsies of asthmatics, asthma in remission and healthy subjects
The study focus was differential expression in bronchial biopsies between persistent asthma, asthma in remission and healthy controls using RNAseq.
EGAS00001003735 | EGA
ProteomicsA label-free proteomics method to investigate the protective effect of Gu-Ben-Fang-Xiao in a chronic persistent murine asthma model
Ethnopharmacological relevance: Gubenfangxiao decoction (GBFXD) is a traditional Chinese medicine formula derived from Yupingfensan, an ancient formula widely used to treat respiratory diseases such as repeated respiratory infection, allergic rhinitis, bronchitis, and asthma. In recent years, GBFXD ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-26 | PXD013244 | Pride
Gubenfangxiao decoction  chronic persistent asthma  label-free proteomic  inflammatory response  immune response 
GenomicsEpigenome-wide association study of asthma remission in whole blood and nasal epithelium
Clinical remission (ClinR) was defined as the absence of asthma symptoms and medication for at least 12 months, and complete remission (ComR) was defined as ClinR with normal lung function and absence of airway hyperresponsiveness. We analyzed differential DNA methylation of ClinR and ComR comparing...
EGAD00010002026 | EGA
GenomicsDNA methylation in bronchial biopsies of asthmatics, asthma in remission and healthy subjects
The study focus was differential methylation in bronchial biopsies between persistent asthma, asthma in remission and healthy controls using Illumina 450k arrays.
EGAS00001003739 | EGA
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [methylation]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40576 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [gene expression]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40732 | biostudies-arrayexpress
TranscriptomicsThe Nasal Gene Expression and Childhood Atopic Asthma
We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma versus healthy controls. We identified 119 differentially methylated regions (DMRs) and 118 differentially methylated probes (DMPs) after adjustment for age, gender, race/ethni...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-GEOD-65204 | biostudies-arrayexpress
TranscriptomicsThe Nasal Methylome and Childhood Atopic Asthma
Background: Nasal epithelia are emerging as a proxy measure of gene expression of the airway epithelium in asthma. We hypothesized that epigenetic marks regulate gene expression of the nasal epithelia and consequently may provide a novel target for allergic asthma. Methods: We compared genom...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-GEOD-65163 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C57BL/6J strain infected with Sendai virus vs. UV irradiated virus to investigate virus-induced airway disease
Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Experiment Overall Design: Whole lung RNA was analyzed from 3 mice per condition per time point for days 2...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10964 | biostudies-arrayexpress
UnknownDysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.
Not available
S-EPMC8622016 | biostudies-literature
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