Sort   by:  
 Page size 
GenomicsCD28 Co-stimulation Drives Tumor-Infiltrating T Cell Glycolysis to Promote Inflammation
CD28 Co-stimulation Drives Tumor-Infiltrating T Cell Glycolysis to Promote Inflammation
PRJNA636802 | ENA
GenomicsOptimized delivery of dual co-stimulation and anti-tumor activity using parallel chimeric antigen receptors (pCARs)
Optimized delivery of dual co-stimulation and anti-tumor activity using parallel chimeric antigen receptors (pCARs)
PRJNA774513 | ENA
Genomics2B4 Co-Stimulation and Dasatinib Modulation Enhance Anti-CD19 CAR-NK Cell Cytotoxicity
2B4 Co-Stimulation and Dasatinib Modulation Enhance Anti-CD19 CAR-NK Cell Cytotoxicity
PRJNA1312063 | ENA
GenomicsCo-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells
PRJNA675632 | ENA
GenomicsTIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation
TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation
PRJNA911822 | ENA
GenomicsATAC-seq of OT-I cells co-cultured with vehicle or TAMos under OVA257-264 stimulation
ATAC-seq of OT-I cells co-cultured with vehicle or TAMos under OVA257-264 stimulation
PRJNA932825 | ENA
GenomicsRNA-seq of OT-I cells co-cultured with vehicle, TANs or TAMos under OVA257-264 stimulation
RNA-seq of OT-I cells co-cultured with vehicle, TANs or TAMos under OVA257-264 stimulation
PRJNA932823 | ENA
TranscriptomicsCD28 Co-stimulation Drives Tumor-Infiltrating T Cell Glycolysis to Promote Inflammation
Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can be suppressed in T cells subjected to unique microenvironments, such as in a tumor. We previously showed that glycolytic and mitochondrial adaptations directly contribute to reduced effector function...
ORGANISM(S): Homo sapiens 
2020-08-10 | GSE151669 | GEO
UnknownMolecular mechanisms of T cell co-stimulation and co-inhibition.
Not available
S-EPMC3786574 | biostudies-literature
TranscriptomicsOptimized delivery of dual co-stimulation and anti-tumor activity using parallel chimeric antigen receptors (pCARs)
Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. Third generation (3G) CARs extend this linear blueprint by fusing both co-stimulatory units in series. However, clinical impact has ...
ORGANISM(S): Homo sapiens 
2021-12-10 | GSE186557 | GEO
Sort   by:  
 Page size