Sort   by:  
 Page size 
MetabolomicsGut Microbiota-Mediated Conversion of Coenzyme A in Vitro

The bacterium Roseburia inulinivorans harbors enzymes predicted to be involved in coenzyme A (CoA) metabolism. To experimentally validate the source of pantetheine, we performed an in vitro co-culture of R. inulinivorans with CoA and analyzed metabolomic profiles. The results demonstrated a signi...

2025-10-15 | MTBLS13143 | MetaboLights
TranscriptomicsGene expression in the mitochondrial syndrome of coenzyme Q deficiency
Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse est...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-33940 | biostudies-arrayexpress
TranscriptomicsCommon gene expression profile in the mitochondrial syndrome of coenzyme Q deficiency
Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse est...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-33769 | biostudies-arrayexpress
ProteomicsIdentification of the proteins involved in the uptake of coenzyme Q
Ubiquinone (UQ), also known as “coenzyme Q” is an essential player in the mitochondrial respiratory electron transport chain as well as a lipid-soluble antioxidant in eukaryotic cells. In this study, we attempted to identify the proteins involved in the pathway by which the exogenous UQ is taken up ...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-06-25 | PXD049194 | JPOST Repository
ProteomicsTranscriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
Abstract Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. Here, we present comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-09 | PXD035880 | Pride
Mitochondria Coenzyme q Lfq Mouse 
TranscriptomicsCoenzyme Q10-dependent gene expression in SAMP1 mice tissues
Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (QH2, 500 mg/ kg BW/ day) of coenzyme Q10 (CoQ10). To unravel molecular mechanisms of these CoQ10 effects, a genome-wide transcript profi...
ORGANISM(S): Mus musculus 
2010-03-15 | E-GEOD-15129 | biostudies-arrayexpress
GenomicsCoenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses
Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses
PRJNA698619 | ENA
TranscriptomicsHost cell-free growth of the Q fever bacterium Coxiella burnetii
The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Q...
ORGANISM(S): Coxiella burnetii 
2010-06-20 | E-GEOD-13338 | biostudies-arrayexpress
GenomicsMitochondrial coenzyme Q redox balance restrains dopaminergic neuron activity to promote early-life sleep in Drosophila
Mitochondrial coenzyme Q redox balance restrains dopaminergic neuron activity to promote early-life sleep in Drosophila
PRJNA1479641 | ENA
TranscriptomicsMitochondrial coenzyme Q redox balance restrains dopaminergic neuron activity to promote early-life sleep in Drosophila
Sleep is especially abundant during early life, yet the cellular mechanisms that maintain elevated juvenile sleep drive remain poorly understood. To identify cell-intrinsic regulators of juvenile sleep, we profiled gene expression in Drosophila dopaminergic neurons (DANs) at different ages and perfo...
ORGANISM(S): Drosophila melanogaster 
2026-06-22 | GSE335815 | GEO
Sort   by:  
 Page size