contusion sci - OmicsDI

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[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate (1)
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Lab affiliation

1. School of Pharmacy and Bioengineering, Keele University, Keele, Staffordshire, UK 2. Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, UK. (1)
Core Facility for Mass Spectrometry and Proteomics, Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany (1)
MaineHealth Institute for Research, Director, Proteomics and Lipidomics Core (1)

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PROTEOMIC IDENTIFICATION OF SYSTEMIC BIOMARKERS IN RAT MODELS OF SPINAL CORD INJURY

Biomarkers to more accurately determine severity and prognosis following spinal cord injury (SCI) are needed to ensure that patients are assigned to the most suitable treatment and rehabilitation regimes. This study aimed to characterise the blood proteome following SCI in clinical rat injury models...

ORGANISM(S): Rattus norvegicus (Rat)

2022-05-19 | PXD021137 | Pride

trkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)

We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes ...

ORGANISM(S): Mus musculus

2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress

Molecular responses in skeletal muscles following spinal cord injury and the effect of locomotor training

Spinal cord injury (SCI) is one of the most disabling health problems facing adults today. Locomotor training has been shown to induce substantial recovery in muscle size and muscle function in both transected and contusion injury animal models of SCI. The overall objective of this study is to impl...

ORGANISM(S): Rattus norvegicus

2015-06-30 | E-GEOD-45550 | biostudies-arrayexpress

Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury

We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates...

ORGANISM(S): Mus musculus

2015-06-27 | E-GEOD-70302 | biostudies-arrayexpress

Differential gene expression following SCI in trkB.T1 null

We asked what genes are significantly differentially regulated in the spinal cord of SCI trkB.T1 WT and trkB.T1 KO mice. TrkB.T1 is upregulated shortly after SCI although the precise mechanisms underyling this upregulation are poorly understood. In the trkB.T1 null, we show less mechanical allodynia...

ORGANISM(S): Mus musculus

2015-12-07 | E-GEOD-42828 | biostudies-arrayexpress

Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury_human data

We conducted a randomized controlled clinical trial investigating the effects of resistance exercise therapy for incomplete SCI. We integrated the analysis of plasma proteomics to explore the molecular and cellular changes induced by resistance exercise.

ORGANISM(S): Homo Sapiens

2025-01-26 | PXD060193 |

Transcription profiling of rat spinal cord contusion 35 days after injury

Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabo...

ORGANISM(S): Rattus norvegicus

2007-10-08 | E-GEOD-2599 | biostudies-arrayexpress

RNA-Seq characterization of spinal cord injury transcriptome in acute/subacute phases: a resource for understanding the pathology at the systems level

Purpose: Spinal cord injury (SCI) is a devastating neurological disease without effective treatment. To generate a comprehensive view of the mechanisms involved in SCI pathology, we applied RNA-sequencing (RNA-seq) technology to characterize the temporal changes in global gene expression after contu...

ORGANISM(S): Mus musculus

2013-08-22 | E-GEOD-45376 | biostudies-arrayexpress

miRNA expression after moderate Spinal Cord Injury in Rats

Identification of temporal variations in miRNA expression after spinal cord injury caused by thoracic (T8) moderate (200 Kdynes) contusion. Expression changes were analyzed 1, 3 and 7 days after injury and compared to expression of control (untreated) and sham (laminectony but no contusion) individu...

ORGANISM(S): Rattus norvegicus

2011-07-01 | E-GEOD-19890 | biostudies-arrayexpress

Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat.

Not available

S-EPMC12400786 | biostudies-literature

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