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ProteomicsModel-driven analysis reveals oxidative stress adaptation enabling efficient energy utilization in a Crabtree-negative Saccharomyces cerevisiae.
The metabolic engineering of Saccharomyces cerevisiae to abolish the Crabtree effect via a pyruvate dehydrogenase bypass has enabled growth in minimal medium with glucose as the sole carbon source, although at a low growth rate. Adaptive laboratory evolution of the engineered strain (sZJD23), follow...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-13 | PXD074337 | Pride
Microbiology  saccharomyces cerevisiae  metabolism  crabtree 
UnknownTransient-state analysis of metabolic fluxes in crabtree-positive and crabtree-negative yeasts.
Not available
S-EPMC183316 | biostudies-literature
TranscriptomicsA single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii
The Crabtree phenotype defines whether a yeast can perform simultaneous respiration and fermentation under aerobic conditions at high growth rates, a phenomenon that resembles the Warburg effect in cancer cells. Whole genome duplication, global promoter rewiring and loss of respiratory complex I are...
ORGANISM(S): Komagataella phaffii 
2018-10-19 | GSE110624 | GEO
GenomicsA single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii
A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii
PRJNA434119 | ENA
GenomicsRNA-seq of hydroxy-acid producing strains of Crabtree-negative Saccharomyces cerevisiae
RNA-seq of hydroxy-acid producing strains of Crabtree-negative Saccharomyces cerevisiae
PRJEB30893 | ENA
UnknownGlobal rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative.
Not available
S-EPMC6076296 | biostudies-literature
GenomicsSaccharomyces cerevisiae
saccharomyces cerevisiae Transcriptome of Crabtree effect
PRJNA803943 | ENA
UnknownAdaptations in metabolism and protein translation give rise to the Crabtree effect in yeast.
Not available
S-EPMC8713813 | biostudies-literature
UnknownA single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii.
Not available
S-EPMC6249229 | biostudies-literature
UnknownCrabtree effect in kidney proximal tubule cells via late-stage glycolytic intermediates.
Not available
S-EPMC10119590 | biostudies-literature
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