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GenomicsThe nutrient sensor CRTC and Sarcalumenin/Thinman represent a new pathway in cardiac hypertrophy
The nutrient sensor CRTC and Sarcalumenin/Thinman represent a new pathway in cardiac hypertrophy
PRJNA1131800 | ENA
TranscriptomicsThe nutrient sensor CRTC and Sarcalumenin/Thinman represent a new pathway in cardiac hypertrophy
CREB-Regulated Transcription Co-activator (CRTC) regulates metabolism in liver where activation by calcineurin regulates gluconeogenic genes. CaN also has roles in pathological cardiac hypertrophy, however cardiac roles for CRTC have not been identified. In Drosophila, CRTC null mutants exhibit seve...
ORGANISM(S): Drosophila melanogaster 
2024-07-29 | GSE271481 | GEO
GenomicsThe CRTC-1 transcriptional domain is required for COMPASS complex mediated longevity in C. elegans
The CRTC-1 transcriptional domain is required for COMPASS complex mediated longevity in C. elegans
PRJNA999718 | ENA
GenomicsGenome-wide maps of CREB/CRTC binding in Drosophila mushroom body.
Purpose: Exploring the alteration in CREB/CRTC binding related to long-term memory Methods: The nuclei of Drosophila mushroom bodies were purified and the histone acetylation and CREB/CRTC binding were examined by ChIP-seq using specific antibodies. The sequencing was performed using Miseq, and alig...
ORGANISM(S): Drosophila melanogaster 
2017-02-09 | GSE81456 | GEO
UnknownCRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.
Not available
S-EPMC5005998 | biostudies-literature
UnknownThe nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy.
Not available
S-EPMC11402474 | biostudies-literature
GenomicsDrosophila CRTC promotes starvation resistance by modulating one-carbon metabolism and insulin signaling
Drosophila CRTC promotes starvation resistance by modulating one-carbon metabolism and insulin signaling
PRJNA658365 | ENA
UnknownActivation of the adipocyte CREB/CRTC pathway in obesity.
Not available
S-EPMC8536733 | biostudies-literature
UnknownCrtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling.
Not available
S-EPMC8000278 | biostudies-literature
TranscriptomicsNeuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal
Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the ‘CREB regulated trans...
ORGANISM(S): Caenorhabditis elegans 
2015-02-27 | GSE58931 | GEO
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