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Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations
Setd2 methylate the nucleosome to form H3K36me3. Here we utilized the Cryo-EM to elucidate the structure of SETD2/Set2 bound with nucleosomes. Through this structure analysis, we found that histone H1 may interfere the enzymatic activity of SETD2/Set2 by inhibiting their binding affinity.
ORGANISM(S): Homo sapiens 
2021-05-20 | GSE148235 | GEO
Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1
The deposited data concern the mapping of acetylation sites on wild-type and the K280A, Y363A mutants of Elp3 by LC-MS/MS. Abstract of the manuscript: tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
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