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ProteomicsA proteomic study on the membrane protein fraction of T cells confirms high substrate selectivity for the ER translocation inhibitor cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of type I integral membrane protein human CD4 (huCD4) across the ER in a signal peptide (SP)-dependent way. Previously, sortilin was identified as a secondary substrate for CADA but showed reduced CADA sensitivity as compare...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD027712 | Pride
Cd4  cyclotriazadisulfonamide (cada)  er co-translational translocation  signal peptide  silac 
UnknownReduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds.
Not available
S-EPMC10501753 | biostudies-literature
UnknownCutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies.
Not available
S-EPMC11607333 | biostudies-literature
UnknownA Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Not available
S-EPMC5294205 | biostudies-literature
UnknownTuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies.
Not available
S-EPMC7006954 | biostudies-literature
UnknownPreprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide.
Not available
S-EPMC6980386 | biostudies-literature
UnknownHuman immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility.
Not available
S-EPMC2738218 | biostudies-literature
UnknownSmall Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes.
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S-EPMC8097030 | biostudies-literature
UnknownA Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide.
Not available
S-EPMC8477212 | biostudies-literature
UnknownStructural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.
Not available
S-EPMC9984176 | biostudies-literature
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