Sort   by:  
 Page size 
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
TranscriptomicsTranscription profiling of humoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8
From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H16...
ORGANISM(S): Homo sapiens 
2006-01-23 | E-TABM-71 | biostudies-arrayexpress
TranscriptomicsA microRNA-directed program of cytotoxic CD8+ T cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse control cell line and a cell line surviving exposure to tumor-specific CTL (cytolytic T lymphocyte)
The CMS4 sarcoma, kindly provided by A. DeLeo (University of Pittsburgh, Pittsburgh, PA), is a solid tumor of BALB/c (H-2d) origin, which grows aggressively in naive, syngeneic hosts following a s.c. transplant. Although the parental tumor cell line forms few metastatic foci in the lungs following i...
ORGANISM(S): Mus musculus 
2005-05-08 | E-MEXP-287 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human CMV (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type CD8+ T cells with constitutive cytolytic activity, but the molecular pathways involved in the ind...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-24151 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239
CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is unclear to what extent the viral suppression mediated by CD8+ T-cells reflects direct killing of infected cells as opposed to indirect, non-cytolytic mechanisms. In this study, we used functional genomics to ...
ORGANISM(S): Macaca mulatta 
2013-02-08 | E-GEOD-37834 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human effector CD8+ T cell subsets
Effector CD8+ T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INF-M-NM-3 and TNF-M-NM-1. We investigated the difference between CXCR1+ and CXCR1- subsets of human effector CD27-CD28-CD8+ T cells. Both subsets...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-26890 | biostudies-arrayexpress
TranscriptomicsCD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients
We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of ...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-MTAB-3266 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of OT-I CD8+ T cells after stimulation with different affinity ligands
Activation of CD8+ T cells depends exquisitely on the affinity of the T cell receptor (TCR) for a peptide MHC (pMHC) ligand complex. Here, we activated OT-I transgenic CD8+ T cells with pure peptide and examined early activation responses by single-cell RNA-sequencing. T cells were activated with th...
ORGANISM(S): Mus musculus 
2018-06-25 | E-MTAB-6051 | biostudies-arrayexpress
TranscriptomicsIL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8+ T cells, but their distinct effects on antigen-driven differentiation of naïve CD8+ T cells into effector CD8+ T cells are not clearly understood. We found t...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10403 | biostudies-arrayexpress
Sort   by:  
 Page size