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Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_targeted metabolites

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-16 | MTBLS12731 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
GenomicsCytosolic N6AMT1-dependent translation supports mitochondrial RNA processing [Ribo-seq]
Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing [Ribo-seq]
PRJNA1109711 | ENA
GenomicsCytosolic N6AMT1-dependent translation supports mitochondrial RNA processing [RNA-Seq]
Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing [RNA-Seq]
PRJNA1109712 | ENA
ProteomicsRedox regulation of cytosolic translation in rice during fungal infection identified by quantitative proteomics
Pathogen attack can increase plant levels of reactive oxygen species (ROS), which then act as signaling molecules activating plant defense. Elucidating these processes is crucial to understanding the redox signaling pathways in plant defense responses. By an iodo TMT–based quantitative proteomic app...
ORGANISM(S): Oryza sativa (Rice) 
2023-06-06 | PXD034430 | Pride
Ros  protein oxidation  translation  infection  immunity  rice 
TranscriptomicsRadiation-induced gene translation profiles reveal tumor type and cancer specific components
The goal of this study was to compare the radiation-induced gene translation profiles generated from human tumor cell lines that are treated with radiation. Keywords: stimulus or stress design A panel of cell lines included 5 gliomas, 4 pancreatic carcinomas, 3 breast carcinomas and 2 non-small cell...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-10547 | biostudies-arrayexpress
UnknownSynchronized mitochondrial and cytosolic translation programs.
Not available
S-EPMC4964289 | biostudies-literature
GenomicsInhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans
Inhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans
PRJNA1228623 | ENA
TranscriptomicsGenome-wide analysis of host mRNA translation during hepatitis C virus infection
Sucrose gradient ultracentrifugation followed by microarray analysis was used to identify translationally-regulated mRNAs (mRNAs associated with ribosomes) from JFH1-infected and uninfected Huh-7.5.1 cells. Huh7 cells were infected with HCV JFH-1 strain. Controls consisted in non-infected cells and ...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44210 | biostudies-arrayexpress
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