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ProteomicsSerum proteomics of T2DM individuals with HFpEF after dapagliflozin treatment by tandem mass spectrometry
A quantitative proteomic profiling by TMT was performed on serum of T2DM individuals with or without dapagliflozin treatment
ORGANISM(S): Homo Sapiens 
PXD037538 |
GenomicsProximal tubular epithelial specific transcriptomics of diabetic mice treated with dapagliflozin
Proximal tubular epithelial specific transcriptomics of diabetic mice treated with dapagliflozin
PRJNA770888 | ENA
ProteomicsDapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis
Male infertility is one of the most common complications of diabetes mellitus (DM). Dapagliflozin is widely used to manage the type II DM. This study aimed to assess the dapagliflozin’s effects on the spermatogenesis by administering either dapagliflozin (Dapa) or a vehicle (db) to diabetic male db/...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-04 | PXD034622 | Pride
Diabetic male infertility  dapagliflozin  gut microbiota  metabolites  testicular protein expression 
TranscriptomicsProximal tubular epithelial specific transcriptomics of diabetic mice treated with dapagliflozin
We show the proximal tubular specific pathway analysis demonstrating the downregulation of oxidative phosphorylation in dapagliflozin treated db/db mice, a type 2 diabetic model. After 8-week treatment of dapagliflozin for db/db mice having proximal tubule specific tdTomato reporter, tdTomato-positi...
ORGANISM(S): Mus musculus 
2022-09-28 | GSE185801 | GEO
GenomicsAnalysis of differential genes in myocardial hypertrophy mice treated with dapagliflozin
Analysis of differential genes in myocardial hypertrophy mice treated with dapagliflozin
PRJNA759225 | ENA
GenomicsAnalysis of the SGLT2-independent off-target dapagliflozin activity using model organism Caenorhabditis elegans
Analysis of the SGLT2-independent off-target dapagliflozin activity using model organism Caenorhabditis elegans
PRJNA1322510 | ENA
TranscriptomicsAnalysis of differential genes in myocardial hypertrophy mice treated with dapagliflozin
The purpose of this study was to investigate the effect of dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, on relieving cardiac hypertrophy and its potential molecular mechanism. Dapagliflozin activated the Plin5/PPARα signaling axis and exerts a protective effect against cardiac h...
ORGANISM(S): Mus musculus 
2021-09-01 | GSE183120 | GEO
TranscriptomicsDapagliflozin protects against chronic heart failure in mice via inhibiting macrophage-mediated inflammation, independent of SGLT2 [RNA-Seq]
The specific mechanism of sodium-glucose cotransporter 2 (SGLT2) inhibitor in heart failure (HF) needs to be elucidated. In this study, we use SGLT2 global knockout (SGLT2-KO) mice to assess the mechanism of SGLT2 inhibitor on HF. Dapagliflozin ameliorates both myocardial infarction (MI)-and transve...
ORGANISM(S): Mus musculus 
2023-11-14 | GSE247062 | GEO
GenomicsDapagliflozin protects against chronic heart failure in mice via inhibiting macrophage-mediated inflammation, independent of SGLT2 [RNA-Seq]
Dapagliflozin protects against chronic heart failure in mice via inhibiting macrophage-mediated inflammation, independent of SGLT2 [RNA-Seq]
PRJNA1036179 | ENA
TranscriptomicsAnalysis of the SGLT2-independent off-target dapagliflozin activity using model organism Caenorhabditis elegans
Flozins, an emerging class of antidiabetic agents, selectively target the SGLT2 sodium/glucose cotransporter in the renal proximal tubule, thereby preventing glucose reabsorption and reducing hyperglycemia. Beyond their primary glucose-lowering mechanism, flozins exhibit significant benefits for hea...
ORGANISM(S): Caenorhabditis elegans 
2026-09-01 | GSE307680 | GEO
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