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TranscriptomicsA Molecular Portrait Of High-Grade Ductal Carcinoma In Situ (DCIS) [RNA-seq]
DCIS is a non-invasive precursor lesion to invasive breast carcinoma. We still have no understanding on why only some DCIS lesions evolve to invasive cancer while others appear not to do so during the life span of the patient. Here, we performed full exome (tumor vs. matching normal), transcriptome ...
ORGANISM(S): Homo sapiens 
2015-07-25 | E-GEOD-69240 | biostudies-arrayexpress
TranscriptomicsGene Expression and Comparative Genomic Hybridization of Ductal Carcinoma In Situ of the Breast
Background The dramatic increase in incidence of ductal carcinoma in situ (DCIS) associated with mammographic screening for breast cancer has given emphasis to the challenges of managing this important clinical entity. Unlike invasive breast cancer, there is no established histopathologic grading sy...
ORGANISM(S): Homo sapiens 
2008-11-24 | E-GEOD-7882 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human DCIS and invasive ductal breast carcinoma
Human healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasiv...
ORGANISM(S): Homo sapiens 
2011-04-11 | E-GEOD-21422 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine DCIS and invasive ductal breast carcinoma
Murine healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasi...
ORGANISM(S): Mus musculus 
2011-04-11 | E-GEOD-21444 | biostudies-arrayexpress
TranscriptomicsIdentification of copy number alterations associated with the progression of DCIS to Invasive Ductal Carcinoma
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma (IDC). Annotation of the genetic differences between the two lesions may assist in the identification of genes that promote the invasive phenotype. Matched IDC and DCIS showed highly similar copy number profile...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-31892 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of patient's DCIS-IDC tandem lesions by RNA sequencing analysis
Tandem DCIS/IDC are defined as ductal carcicnoma in situ (DCIS) lesions that have concurrent invasive ductal carcinoma (IDC) within the same breast. These are identified radiologically by an area of clustered microcalcifications adjacent to (contiguous with) an invasive mass. Our radiologist (Dr. Wi...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-GEOD-66301 | biostudies-arrayexpress
TranscriptomicsDifferentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 3)
We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression. RNA from human samples were extracted, purified, amplified, and evaluated for gene expression using Affymetrix U95Av2 gene expression arrays.
ORGANISM(S): Homo sapiens 
2012-09-29 | E-GEOD-41197 | biostudies-arrayexpress
GenomicsA Molecular Portrait Of High-Grade Ductal Carcinoma In Situ (DCIS) [RRBS-seq]
DCIS is a non-invasive precursor lesion to invasive breast carcinoma. We still have no understanding on why only some DCIS lesions evolve to invasive cancer while others appear not to do so during the life span of the patient. Here, we performed full exome (tumor vs. matching normal), transcriptome ...
ORGANISM(S): Homo sapiens 
2015-07-25 | E-GEOD-69993 | biostudies-arrayexpress
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
TranscriptomicsExpression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (microRNA)
Introduction: microRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression and may play a causal role in invasive breast cancer. Since many genetic aberrations of invasive disease are detectable in earlier stages, we hypothesized that miRNA expression dysregulation and the p...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-24508 | biostudies-arrayexpress
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