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GenomicsSecretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins
Secretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins
PRJNA662582 | ENA
UnknownHarnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
Not available
S-EPMC9189052 | biostudies-literature
UnknownCell-Free Systems Based on CHO Cell Lysates: Optimization Strategies, Synthesis of "Difficult-to-Express" Proteins and Future Perspectives.
Not available
S-EPMC5042383 | biostudies-literature
TranscriptomicsSecretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins
Biologics have emerged as leading blockbuster therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here we identify bottlenecks limiting expression of challenging recombinant human proteins through a systems biology analysis of the transcriptomes of CHO and HEK29...
ORGANISM(S): Homo sapiens Cricetulus griseus 
2022-06-22 | GSE157729 | GEO
UnknownImproving expression and assembly of difficult-to-express heterologous proteins in Saccharomyces cerevisiae by culturing at a sub-physiological temperature.
Not available
S-EPMC10035479 | biostudies-literature
UnknownA protein chimera strategy supports production of a model "difficult-to-express" recombinant target.
Not available
S-EPMC6174982 | biostudies-literature
UnknownmiRNA engineering of CHO cells facilitates production of difficult-to-express proteins and increases success in cell line development.
Not available
S-EPMC6084326 | biostudies-literature
UnknownA robust antibody discovery platform for difficult-to-express G protein-coupled receptors.
Not available
S-EPMC9793966 | biostudies-literature
TranscriptomicsExpression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
This SuperSeries is composed of the following subset Series: GSE25886: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in 3 mouse cell lines: AtT20, BV2 and N18 GSE25894: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in the HEK293 cell line Refer to individu...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-25901 | biostudies-arrayexpress
UnknownFAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in Drosophila S2 Cells.
Not available
S-EPMC9117644 | biostudies-literature
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