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MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
UnknownThe sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria.
Not available
S-EPMC3258934 | biostudies-literature
UnknownRenal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.
Not available
S-EPMC6026009 | biostudies-literature
UnknownDipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
Not available
S-EPMC8809686 | biostudies-literature
UnknownDexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.
Not available
S-EPMC8809683 | biostudies-literature
ProteomicsMechanisms of Resistance to Prostate-Specific Membrane Antigen-Targeted Radioligand Therapy in a Mouse Model of Prostate Cancer
Purpose: Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) is effective against prostate cancer (PCa), but all patients relapse eventually. Poor understanding of the underlying resistance mechanisms represents a key barrier to development of more effective RLT. We investigat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-04 | MSV000086408 | MassIVE
TranscriptomicsFlavivirus antagonism of type I interferon signaling reveals prolidase as a regulator of IFNAR1 trafficking and expression
Type I interferon (IFN-I) signals through two receptor subunits, IFNAR1 and IFNAR2, to regulate sterile and infectious immunity. IFNAR1 expression is tightly regulated to prevent autoimmunity although the mechanisms governing this are incompletely understood. We investigated the strategies used by t...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-64387 | biostudies-arrayexpress
UnknownIdentification of a staphylococcal dipeptidase involved in the production of human body odor.
Not available
S-EPMC11742315 | biostudies-literature
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
ProteomicsDiscovery of a testis-specific complex TEX101-DPEP3 and selection of its disrupting antibodies
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa tra...
ORGANISM(S): Homo sapiens (Human) 
2018-08-16 | PXD007515 | Pride
Tex101  testis-expressed sequence 101 protein  dpep3  dipeptidase 3  affinity purification-mass spectrometry  interactome  protein-protein interactions  testis-specific proteins  spermatozoa  disrupting antibodies 
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