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Modelling Approach

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Technical University of Munich (TUM), TUM School of Natural Sciences, Department Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Ernst-Otto-Fischer Str. 8, Garching 85748, Germany (1)
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IsPrivate

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protozoa (1)

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Solvent-Induced partial Cellular Fixation Approach enables systematic identification of drug targets and temporal progression of downstream biochemical pathways in living cells

In this study, we introduce a novel approach, the Solvent-Induced Partial Cellular Fixation Approach (SICFA), to monitor drug targets and the temporal progression of downstream biochemical pathways in living cells. We observed that proteins in living cells undergo unfolding and aggregation when expo...

ORGANISM(S): Homo sapiens (Human)

2025-10-15 | PXD057157 | Pride