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Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55901 | biostudies-arrayexpress
Transcriptomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [GRO-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55903 | biostudies-arrayexpress
TranscriptomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [Illumina BeadArray]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43624 | biostudies-arrayexpress
GenomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [ChIP-Seq]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43625 | biostudies-arrayexpress
UnknownFunctional characterization of liver enhancers that regulate drug-associated transporters.
Not available
S-EPMC3227682 | biostudies-literature
UnknownThe enantioselective enhancing effect and mechanistic insights of chiral enhancers in transdermal drug delivery.
Not available
S-EPMC10616145 | biostudies-literature
UnknownIdentification of drug responsive enhancers by predicting chromatin accessibility change from perturbed gene expression profiles.
Not available
S-EPMC11139989 | biostudies-literature
GenomicsA generic drug combination synergizes as exercise enhancers to ameliorate various metabolically-related diseases
A generic drug combination synergizes as exercise enhancers to ameliorate various metabolically-related diseases
PRJNA1073195 | ENA
UnknownUnderstanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations.
Not available
S-EPMC10428223 | biostudies-literature
GenomicsGlucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction
Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction
PRJNA797649 | ENA
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