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MetabolomicsAn integrated drug repositioning analysis for sarcopenia

Global population aging with increased longevity has incurred a higher prevalence of sarcopenia. Sarcopenia is characterized by age-related muscle/strength loss and is becoming a highly important public health issue. The development of sarcopenia increases the risk of various adverse health outco...

2026-01-09 | MTBLS9582 | MetaboLights
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
TranscriptomicsExpression of the IL-17/Th17 axis in the development of acute renal allograft rejection
Genesets for the IL-17 pathway and Th17 T-helper cell subtype showed increasing enrichment in 33 pre-transplant donor biopsies and 33 matching post-transplant biopsies from patients with increasing Banff grades of acute rejection (no signficant abnormalities, n=17; borderline, n=4; ARIA, n=7; ARIB, ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-34437 | biostudies-arrayexpress
TranscriptomicsNucleosome Repositioning: Nicotine- and Cocaine-induced Changes
SH-SY5Y, neuroblastoma cells, were exposed to nicotine for 10, 60, and 90 minutes or cocaine for 5, 20, 40, and 60 minutes. Drugs of abuse modify behavior by altering gene expression in the brain. Gene expression can be regulated by changes in DNA methylation as well as by histone modifications, wh...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-71795 | biostudies-arrayexpress
GenomicsA Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis
A Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis
PRJNA1261874 | ENA
GenomicsDiscovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
PRJNA796970 | ENA
UnknownTranscriptome-Guided Drug Repositioning.
Not available
S-EPMC6969900 | biostudies-literature
UnknownDrug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses.
Not available
S-EPMC6346040 | biostudies-literature
UnknownDrug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents.
Not available
S-EPMC9189996 | biostudies-literature
UnknownPrediction of drug-target interactions and drug repositioning via network-based inference.
Not available
S-EPMC3349722 | biostudies-literature
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