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MetabolomicsTargeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase inhibitors (PARPi), such as olaparib, have significantly improved outcomes in ovarian cancer (OC); however, therapy resistance remains a major clinical challenge. Here, we showed that glutamine metabolism was upregulated in PARPi-resistant OC cells and identified the g...

2026-04-08 | MTBLS14072 | MetaboLights
MetabolomicsTargeting secreted MDK-mediated tryptophan/kynurenine metabolism enhances DLL3 CAR T therapy for SCLC

Small cell lung cancer (SCLC) exhibits profound immunometabolic suppression that impairs antigen presentation and constrains immunotherapy efficacy. Through integrated multi-omics analyses of primary human SCLC tumors, we identified midkine (MDK) as a dominant tumor-secreted driver of immune evas...

2026-03-23 | MTBLS14116 | MetaboLights
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
GenomicsDual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumour, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation. Ornithine decarboxyl...
EGAS00001004905 | EGA
GenomicsDual Therapy Targeting Cellular Bioenergetics as Treatment for Pancreatic Cancer
Dual Therapy Targeting Cellular Bioenergetics as Treatment for Pancreatic Cancer
PRJNA1413920 | ENA
GenomicsDual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis
PRJNA1205682 | ENA
GenomicsDual Functions of TAF7L in Adipocyte Differentiation
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and mouse white fat tissue (WAT). Depletion of TAF7L reduced adipocyte-spec...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-41937 | biostudies-arrayexpress
GenomicsDual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [Hi-C]
Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [Hi-C]
PRJNA1111556 | ENA
GenomicsmRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations
mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations
PRJNA853863 | ENA
GenomicsDual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [CUT&RUN]
Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [CUT&RUN]
PRJNA1111557 | ENA
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