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ProteomicsAdenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling
The human adenovirus serotype 5 E4ORF1 (Ad5E4ORF1) protein promotes primary endothelial cell survival and angiocrine functions by hijacking the cellular phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. However, the mechanism by which E4ORF1 activates PI3K in vascular cells remains largely...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069348 | Pride
Adenovirus  akt  angiogenesis  dlg1  e4orf1  endothelium  phosphatidylinositol-3-kinase. 
TranscriptomicsAdenovirus promotes host cell anabolic glucose metabolism via MYC activation
Adenovirus infection leads to increased glycolytic metabolism in host cells. Expression of a single gene product encoded within the E4 early transcription region, E4ORF1, is sufficient to promote increased glycolytic flux in cultured epithelial cells. E4ORF1 reprograms cellular glucose metabolism by...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-52998 | biostudies-arrayexpress
UnknownE4orf1 protein reduces the need for endogenous insulin.
Not available
S-EPMC6534626 | biostudies-literature
UnknownAdenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cells.
Not available
S-EPMC12743444 | biostudies-literature
UnknownAdenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.
Not available
S-EPMC4294542 | biostudies-literature
UnknownE4orf1 improves adipose tissue-specific metabolic risk factors and indicators of cognition function in a mouse model of Alzheimer's disease.
Not available
S-EPMC10423203 | biostudies-literature
UnknownThe adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cells.
Not available
S-EPMC12578350 | biostudies-literature
UnknownE4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte.
Not available
S-EPMC4588421 | biostudies-literature
UnknownHepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation.
Not available
S-EPMC5248996 | biostudies-literature
UnknownE4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet.
Not available
S-EPMC9409018 | biostudies-literature
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