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ProteomicsC-terminal-dependent control of EAAT2 signaling, corticostriatal synaptic glutamate clearance and spontaneous motor activity in mice with hypokinesia
Deficiency of the astrocytic excitatory amino acid transporter type 2 (EAAT2) and, consequently, inefficient glutamate clearance at corticostriatal synapses may contribute to the depression of self-initiated movements in HuntingtonÕs disease (HD). Here we report that the removal of the last 68 amino...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-26 | PXD029194 | Pride
Huntington's disease  eaat2 interaction proteomics  hypokinesia  corticostriatal synaptic transmission  glutamate clearance  synaptic targeting of eaat2 
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